Plasma Lipidomic Profiling in a Military Population of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder with Apolipoprotein E ɛ4–Dependent Effect
| العنوان: | Plasma Lipidomic Profiling in a Military Population of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder with Apolipoprotein E ɛ4–Dependent Effect |
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| المؤلفون: | Scott Ferguson, Tanja Emmerich, Hannah Montague, Justin Martin, Robert Pelot, Gogce Crynen, Alex Bishop, Fiona Crawford, Laila Abdullah, John Phillips, Helena Chaytow, Jon Reed, James E. Evans, Michael Mullan, Michael N. Dretsch, Ghania Ait-Ghezala, Venkatarajan S. Mathura |
| المصدر: | Journal of Neurotrauma. 33:1331-1348 |
| بيانات النشر: | Mary Ann Liebert Inc, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Apolipoprotein E, medicine.medical_specialty, Traumatic brain injury, Apolipoprotein E4, Population, Comorbidity, Severity of Illness Index, behavioral disciplines and activities, Stress Disorders, Post-Traumatic, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, mental disorders, Severity of illness, medicine, Humans, Young adult, education, Brain Concussion, Phospholipids, education.field_of_study, Traumatic stress, medicine.disease, Cross-Sectional Studies, Military Personnel, 030104 developmental biology, Neurology (clinical), Psychology, 030217 neurology & neurosurgery, Psychological trauma, Clinical psychology |
| الوصف: | In the military population, there is high comorbidity between mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) due to the inherent risk of psychological trauma associated with combat. These disorders present with long-term neurological dysfunction and remain difficult to diagnose due to their comorbidity and overlapping clinical presentation. Therefore, we performed cross-sectional analysis of blood samples from demographically matched soldiers (total, n = 120) with mTBI, PTSD, and mTBI+PTSD and those who were considered cognitively and psychologically normal. Soldiers were genotyped for apolipoprotein E (APOE) ɛ4, and phospholipids (PL) were examined using liquid chromatography/mass spectrometry analysis. We observed significantly lower levels of several major PL classes in TBI, PTSD, and TBI+PTSD, compared with controls. PTSD severity analysis revealed that significant PL decreases were primarily restricted to the moderate-to-severe PTSD group. An examination of the degree of unsaturation showed that monounsaturated fatty acid-containing phosphatidylcholine (PC) and phosphatidylinositol (PI) species were lower in the TBI and TBI+PTSD groups. However, these PLs were unaltered among PTSD subjects, compared with controls. Similarly, ether PC (ePC) levels were lower in PTSD and TBI+PTSD subjects, relative to controls. Ratios of arachidonic acid (AA) to docosahexaenoic acid (DHA)-containing species were significantly decreased within PC and phosphatidylethanolamine (PE) classes. APOE ɛ4 (+) subjects exhibited higher PL levels than their APOE ɛ4 (-) counterparts within the same diagnostic groups. These findings suggest that PL profiles, together with APOE genotyping, could potentially aid to differentiate diagnosis of mTBI and PTSD and warrant further validation. In conclusion, PL profiling may facilitate clinical diagnosis of mTBI and PTSD currently hindered by comorbid pathology and overlapping symptomology of these two conditions. |
| تدمد: | 1557-9042 0897-7151 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f42659f87080fa51f80e26fefd2302f https://doi.org/10.1089/neu.2015.4061 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6f42659f87080fa51f80e26fefd2302f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
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