A Dominant Trait Linked to Chromosome 1 in DBA/2 Mice for the Resistance to Autoimmune Gastritis Appears in Bone Marrow Cells
| العنوان: | A Dominant Trait Linked to Chromosome 1 in DBA/2 Mice for the Resistance to Autoimmune Gastritis Appears in Bone Marrow Cells |
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| المؤلفون: | Kenji Suzuki, Satoru Suenaga, Yoshihiro Kushida, Maki Touma, Masamichi Hosono, Mariko Wakatsuki, Masato Fujii |
| المصدر: | Experimental Animals |
| بيانات النشر: | Japanese Association for Laboratory Animal Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Atrophic gastritis, Autoimmune Gastritis, Original, T-Lymphocytes, Locus (genetics), Bone Marrow Cells, Biology, medicine.disease_cause, Lymphocyte Activation, General Biochemistry, Genetics and Molecular Biology, Autoimmunity, Autoimmune Diseases, Chimera (genetics), Mice, thymus, medicine, Animals, Humans, Dba 2 mice, mouse, Disease Resistance, Genes, Dominant, Mice, Inbred BALB C, General Veterinary, Chimera, autoimmunity, gastritis, General Medicine, medicine.disease, Molecular biology, Chromosomes, Mammalian, Disease Models, Animal, medicine.anatomical_structure, Mice, Inbred DBA, Immunology, Cytokines, Animal Science and Zoology, Female, Bone marrow, Gastritis, medicine.symptom, human activities |
| الوصف: | Neonatal thymectomy (NTx) induces autoimmune gastritis (AIG) in BALB/c mice, a model for human type A chronic atrophic gastritis, but not in DBA/2 mice and rarely in CDF1 mice (a hybrid of BALB/c and DBA/2 mice). The aim of this study was to clarify the mechanisms of AIG-resistance in mice bearing the dominant trait of DBA/2. Linkage groups associated with, and cells related to AIG resistance were examined with CDF1-BALB/c backcrosses. Intracellular staining and flow-cytometric bead array for several cytokines were performed on NTx BALB/c mice and NTx DBA/2-chimeric BALB/c mice receiving DBA/2-bone marrow cells. In NTx BALB/c mice, IFN-γ-secreting CD4(+) T cells were increased, but not in NTx DBA/2 mice. Because Vβ6(+) T cell-bearing mice of half of their backcrosses developed AIG, but the other half of Vβ6(+) T cell-negative mice developed scarcely, resistance for AIG generation is associated with the presence of the Mls-1a locus on chromosome 1 in DBA/2 mice, which deletes Vβ6(+) T cells. NTx DBA/2-chimera BALB/c mice showed dominant production of IL-10 and resistance for AIG, although the deletion of Vβ6(+) T cells was found not to be a cause of AIG-resistance from Mls-1a locus segregation experiments. Although NTx DBA/2-chimeric BALB/c mice did not suffer from AIG, they brought immediate precursors of T cells for AIG. It is concluded that DBA/2 mice generate bone marrow-derived cells that produce anti-inflammatory cytokines to prevent the activation of AIG-T cells. |
| اللغة: | English |
| تدمد: | 1881-7122 1341-1357 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6a2e3f697d61e327d269b69af191c0 http://europepmc.org/articles/PMC4160989 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6f6a2e3f697d61e327d269b69af191c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18817122 13411357 |
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