Chronic kidney disease progression among patients with type 2 diabetes identified in US administrative claims: a population cohort study
| العنوان: | Chronic kidney disease progression among patients with type 2 diabetes identified in US administrative claims: a population cohort study |
|---|---|
| المؤلفون: | Csaba P Kovesdy, Danielle Isaman, Natalia Petruski-Ivleva, Linda Fried, Michael Blankenburg, Alain Gay, Priscilla Velentgas, Kerstin Folkerts |
| المصدر: | Clinical Kidney Journal |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Population, 030232 urology & nephrology, Psychological intervention, Renal function, Type 2 diabetes, urologic and male genital diseases, 03 medical and health sciences, chemistry.chemical_compound, disease progression, 0302 clinical medicine, Internal medicine, eGFR, Medicine, 030212 general & internal medicine, Stage (cooking), AcademicSubjects/MED00340, education, Transplantation, Creatinine, education.field_of_study, real-world data, business.industry, Original Articles, medicine.disease, chemistry, Nephrology, type 2 diabetes, business, UACR, chronic kidney disease, Cohort study, Kidney disease |
| الوصف: | Background Chronic kidney disease (CKD), one of the most common complications of type 2 diabetes (T2D), is associated with poor health outcomes and high healthcare expenditures. As the CKD population increases, a better understanding of the prevalence and progression of CKD is critical. However, few contemporary studies have explored the progression of CKD relative to its onset in T2D patients using established markers derived from real-world care settings. Methods This retrospective, population-based cohort study assessed CKD progression among adults with T2D and with newly recognized CKD identified from US administrative claims data between 1 January 2008 and 30 September 2018. Included were patients with T2D and laboratory evidence of CKD as indicated by the established estimated glomerular filtration rate (eGFR) and urine albumin:creatinine ratio (UACR) criteria. Disease progression was described as transitions across the eGFR- and UACR-based stages. Results A total of 65 731 and 23 035 patients with T2D contributed to the analysis of eGFR- and UACR-based CKD stage progression, respectively. CKD worsening was observed in approximately 10–17% of patients over a median follow-up of 2 years. Approximately one-third of patients experienced an increase in eGFR values or a decrease in UACR values during follow-up. Conclusions A relatively high proportion of patients were observed with disease progression over a short period of time, highlighting the need for better identification of patients at risk of rapidly progressive CKD. Future studies are needed to determine the clinical characteristics of these patients to inform earlier diagnostic and therapeutic interventions aimed at slowing disease progression. Graphical Abstract |
| تدمد: | 2048-8513 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f98ae6360f9228a079f20350a9b5163 https://doi.org/10.1093/ckj/sfaa200 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6f98ae6360f9228a079f20350a9b5163 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488513 |
|---|