التفاصيل البيبلوغرافية
العنوان:
Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists
المؤلفون:
Ivo Vranesic , Peter Ertl , Manuel Koller , Grit Laue , Dirk Behnke , David Orain , Sandrine Desrayaud , David Carcache
المصدر:
Bioorganic & Medicinal Chemistry Letters . 22:6454-6459
بيانات النشر:
Elsevier BV, 2012.
سنة النشر:
2012
مصطلحات موضوعية:
Pyridones , Stereochemistry , Metabotropic glutamate receptor 5 , Chemistry , Receptor, Metabotropic Glutamate 5 , Organic Chemistry , Clinical Biochemistry , Allosteric regulation , Pharmaceutical Science , Receptors, Metabotropic Glutamate , Amides , Biochemistry , Inhibitory Concentration 50 , chemistry.chemical_compound , Allosteric Regulation , Solubility , Drug Discovery , Aqueous solubility , Pyridine , Humans , Molecular Medicine , Pyrroles , Metabotropic glutamate receptor 2 , Molecular Biology
الوصف:
1H-pyrrolo[2,3-c]pyridine-7-carboxamides constitute a new series of allosteric mGluR5 antagonists. Variation of the substituents attached to the heterocyclic scaffold allowed to improve the physico-chemical parameters for optimization of the aqueous solubility while retaining high in vitro potency.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc51fe950ab99a627e4927771bfbf5e https://doi.org/10.1016/j.bmcl.2012.08.053
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....6fc51fe950ab99a627e4927771bfbf5e
قاعدة البيانات:
OpenAIRE
