The propensity of invasive circulating tumor cells (iCTCs) in metastatic progression and therapeutic responsiveness
| العنوان: | The propensity of invasive circulating tumor cells (iCTCs) in metastatic progression and therapeutic responsiveness |
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| المؤلفون: | Wen-Tien Chen, Michael L. Pearl, Donghai Chen, Qiang Zhao, Shaun Tulley, Huan Dong, Leong Cho |
| المصدر: | Cancer Medicine Cancer Medicine, Vol 8, Iss 8, Pp 3864-3874 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.drug_class, Population, Monoclonal antibody, lcsh:RC254-282, Metastasis, Immunophenotyping, 03 medical and health sciences, 0302 clinical medicine, Circulating tumor cell, iCTCs, Pancreatic cancer, Cell Line, Tumor, Neoplasms, medicine, Biomarkers, Tumor, Doubling time, Humans, metastasis, Radiology, Nuclear Medicine and imaging, Neoplasm Metastasis, education, Propensity Score, Cell Proliferation, Neoplasm Staging, Original Research, Cancer Biology, education.field_of_study, biology, business.industry, therapy response, CD44, tumor invasion, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Neoplastic Cells, Circulating, 3. Good health, 030104 developmental biology, Treatment Outcome, ovarian cancer, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Disease Progression, Neoplastic Stem Cells, business, Ovarian cancer |
| الوصف: | Circulating tumor cells (CTCs) are important clinical indicators of metastatic progression and treatment efficacy. However, because of their low number and heterogeneity, reliable patient‐derived CTC models are not readily available. We report here the isolation and characterization of the invasive population of CTCs, iCTCs, from blood of 10 patients with epithelial ovarian cancer (EOC) and one pancreatic cancer patient based on the avidity of tumor cells toward an artificial collagen‐based adhesion matrix (CAM), in comparison with tumor progenitor (TP) cells isolated from tumor cell lines, tumors and ascites from EOC patients. CAM‐avid cells identified to be iCTCs were indistinguishable with TP cells using either functional CAM uptake or surface markers (seprase and CD44). In addition, iCTCs were characterized using peritoneal and spontaneous metastasis models in vivo to evaluate their metastatic propensity and therapeutic response. TP cells and iCTCs had a doubling time of about 34‐42 hours. TP cells were rare ( |
| تدمد: | 2045-7634 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd31f5b4c016a6b5463d9d9af1d5a09 https://pubmed.ncbi.nlm.nih.gov/31115187 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6fd31f5b4c016a6b5463d9d9af1d5a09 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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