MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers
| العنوان: | MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers |
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| المؤلفون: | Yves-Marie Pers, Christine Roubert, Fernando Gonzalez, Jacqueline Pefaur, Maroun Khoury, Alejandro Badilla Piñeiro, Fernando E Figueroa, Isabelle Duroux-Richard, Florence Apparailly, Christian Jorgensen, Rosa Chea, Jimena Cuenca, Clara Ponsolles, Roser Areny |
| المساهمون: | Philips, Alexandre, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Universidad de los Andes [Bogota] (UNIANDES), Sanofi-Aventis R&D, SANOFI Recherche, Hospital Félix Bulnes [Santiago, Chile], Hospital Barros Luco [Santiago, Chile], Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2015, 16 (8), pp.16953-16965. ⟨10.3390/ijms160816953⟩ Volume 16 Issue 8 Pages 16953-16965 International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 16953-16965 (2015) |
| بيانات النشر: | MDPI AG, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], Lupus nephritis, lcsh:Chemistry, Pathogenesis, 0302 clinical medicine, Cluster Analysis, Lupus Erythematosus, Systemic, Chile, skin and connective tissue diseases, lcsh:QH301-705.5, Spectroscopy, 0303 health sciences, education.field_of_study, Systemic lupus erythematosus, General Medicine, microRNAs, naive B cells, 3. Good health, Computer Science Applications, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, France, Adult, Naive B cell, Population, B-Lymphocyte Subsets, Biology, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, microRNA, memory B cells, medicine, Humans, Physical and Theoretical Chemistry, education, Molecular Biology, B cell, 030304 developmental biology, lupus nephritis, 030203 arthritis & rheumatology, Gene Expression Profiling, Organic Chemistry, lupus, medicine.disease, Gene expression profiling, lcsh:Biology (General), lcsh:QD1-999, Case-Control Studies, Immunology, Biomarkers |
| الوصف: | International audience; MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE. |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 1661-6596 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70353c54891bc609ab137680b2804074 https://doi.org/10.3390/ijms160816953 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....70353c54891bc609ab137680b2804074 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 16616596 |
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