The association between IUGR and maternal inherited thrombophilias
| العنوان: | The association between IUGR and maternal inherited thrombophilias |
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| المؤلفون: | Svetlana Vrzic Petronijevic, Miloš Petronijević, Filip Djokovic, Katarina Jeremic, Irena Djunic, Stefan Dugalic, Zoran Jokić, Milica Zaric, Ivan Soldatovic, Aleksandar Stefanovic, Igor Pantic, Jelena Dotlic, Jovana Todorovic |
| المصدر: | Medicine |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, unknown cause IUGR, Observational Study, Intrauterine growth restriction, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Inherited thrombophilias, Pregnancy, Plasminogen Activator Inhibitor 1, Humans, Thrombophilia, risk factors, Medicine, 030212 general & internal medicine, Methylenetetrahydrofolate Reductase (NADPH2), reproductive and urinary physiology, Retrospective Studies, Fetal Growth Retardation, 030219 obstetrics & reproductive medicine, Routine screening, business.industry, Obstetrics, Case-control study, Retrospective cohort study, inherited thrombophilia, General Medicine, medicine.disease, female genital diseases and pregnancy complications, 3. Good health, obstetric vascular complications, Case-Control Studies, embryonic structures, Female, Observational study, business, Body mass index, Research Article |
| الوصف: | One of the risk factors for vascular obstetric complications, such as intrauterine growth restriction (IUGR), is inherited thrombophilias. Nevertheless, routine screening for thrombophilias is not endorsed in pregnant women due to their low prevalence and conflicting results of published studies regarding the usefulness of screening in these patients. The cause of IUGR remains unknown in almost 1 quarter of cases. There are no published studies evaluating the association of inherited thrombophilias and IUGR in patients with IUGR of unknown origin. Understanding and preventing IUGR is an important public health concern, as IUGR has been associated with fetal mortality and neonatal morbidity, as well as adverse long-standing consequences. This study aimed to evaluate the prevalence of inherited thrombophilias in IUGR of unknown cause and to test the association between the inherited thrombophilias and IUGR of unknown cause. This study included 33 cases of IUGR of unknown cause tested for inherited thrombophilias and 66 controls individually matched for age, ethnicity, and smoking status. Patients with plasminogen activator inhibitor 1 (PAI-1) and methylenetetrahydrofolate reductase (MTHFR) had significantly higher odds for IUGR of unknown cause (P |
| تدمد: | 1536-5964 0025-7974 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703ae62d16d226787ff4c127f23e9f10 https://doi.org/10.1097/md.0000000000012799 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....703ae62d16d226787ff4c127f23e9f10 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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