The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
| العنوان: | The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population |
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| المؤلفون: | Yan Yang, Qiutang Zeng, Yuhua Liao, Qing Kenneth Wang, Xiuchun Li, Chenhong Zheng, Xu Ma, Fan Wang, Tingting Tang, Rui Yao, Shaofang Nie, Xiang Cheng, Zhenwei Pan, Hao Xia, Lisong Shi, Chengqi Xu, Ni Xia, Yu-he Ke, Qingxian Li, Pengyun Wang, Baofeng Yang, Xin-Xin Yan, Binbin Wang, Yanxia Wu, Yue Li, Xin Tu |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, China, medicine.medical_specialty, Genotype, Endocrinology, Diabetes and Metabolism, Population, Genome-wide association study, Single-nucleotide polymorphism, Coronary Artery Disease, Type 2 diabetes, 030204 cardiovascular system & hematology, Biology, Polymorphism, Single Nucleotide, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Asian People, Gene Frequency, Internal medicine, Genetics, Odds Ratio, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, education, Allele frequency, Alleles, Genetic Association Studies, Coronary atherosclerosis, Aged, 030304 developmental biology, 0303 health sciences, education.field_of_study, Odds ratio, Middle Aged, medicine.disease, 3. Good health, Logistic Models, Diabetes Mellitus, Type 2, Genetic Loci, Case-Control Studies, Chromosomes, Human, Pair 9 |
| الوصف: | OBJECTIVE Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GeneID Chinese Han population to 1) further replicate the association of 9p21.3 type 2 diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess the association of these SNPs with coronary artery disease. RESEARCH DESIGN AND METHODS Three SNPs (rs2383208, rs10811661, and rs10757283) were genotyped in two GeneID cohorts of 3,167 Chinese Han individuals. Case-control association design was used to determine the association of the SNPs with type 2 diabetes and coronary artery disease. Gensini scores were calculated in the coronary artery disease subjects and were tested for association with the variants. Multivariate logistic regressions were performed on association studies. RESULTS The association between two of the three SNPs and type 2 diabetes was replicated in the GeneID population (rs2383208, P = 0.936; rs10811661-T, P = 0.02, odds ratio [OR] = 1.23; rs10757283-C, P = 0.003, OR = 1.30). The same two SNPs also contributed to the risk of coronary artery disease (CAD) (rs10811661-T, P = 0.002, OR = 1.19; rs10757283-C, P = 0.003, OR = 1.18). In addition, rs10757283 was associated with severity of coronary atherosclerosis estimated by the Gensini scoring system (risk allele C, quantitative-trait regression adjusted P = 0.002). CONCLUSIONS For the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rs10811661 and rs10757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GeneID Chinese Han population. |
| تدمد: | 1939-327X 0012-1797 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704632ef7f36e272740d2291cec5fde3 https://doi.org/10.2337/db10-0185 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....704632ef7f36e272740d2291cec5fde3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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