Pros and cons of aminoglutethimide for advanced postmenopausal breast cancer
| العنوان: | Pros and cons of aminoglutethimide for advanced postmenopausal breast cancer |
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| المؤلفون: | Jgm Bonfrèr, E Hamersma-v.d. Linden, E. Engelsman, W Nooyen, Peter F. Bruning, M. de Jong-Bakker |
| المصدر: | Breast Cancer Research and Treatment. 4:289-295 |
| بيانات النشر: | Springer Science and Business Media LLC, 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Hydrocortisone, Thyrotropin, Breast Neoplasms, Drug withdrawal, Breast cancer, Internal medicine, medicine, Humans, business.industry, Primary hypothyroidism, Cancer, Middle Aged, medicine.disease, Aminoglutethimide, Surgery, Clinical trial, Oncology, Toxicity, Female, Menopause, business, medicine.drug |
| الوصف: | In a phase II clinical trial, 38 postmenopausal women with advanced breast cancer were treated with aminoglutethimide and replacement hydrocortisone. All women had previously received up to 4 modalities of endocrine therapy. Seventeen patients had also been treated with cytostatic drugs. Twenty-five percent of the 29 evaluable patients experienced objective tumor regression, lasting from 11 to more than 18 months. In 29% the disease was stabilized for 3 to more than 15 months. Toxicity was significant, necessitating drug withdrawal in 3 patients. One patient died within 3 weeks of therapy from multiple perforated gastric ulcers. Two patients developed herpes zoster within 4 weeks of treatment. Many side effects were minor and transient. However, treatment resulted in overt primary hypothyroidism in 25% of the evaluable patients and in a strongly increased need of acenocoumarin in all 3 patients on anticoagulant therapy. |
| تدمد: | 1573-7217 0167-6806 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706a2be4c856d2a37c608fdc831db3e6 https://doi.org/10.1007/bf01806041 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....706a2be4c856d2a37c608fdc831db3e6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737217 01676806 |
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