Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience
| العنوان: | Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience |
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| المؤلفون: | L K Rajeev, Dipti Panwar, K Govind Babu, K C Lakshmaiah, Abhishek Anand, A H Rudresha, G V Giri, K N Lokesh, D. Lokanatha, Deepak Koppaka, M C Suresh Babu, Smitha Saldanha, Linu Abraham Jacob, Rajesh Patidar |
| المصدر: | South Asian Journal of Cancer, Vol 7, Iss 3, Pp 207-209 (2018) South Asian Journal of Cancer |
| بيانات النشر: | Georg Thieme Verlag KG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, survival, lcsh:RC254-282, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Etoposide, Chemotherapy, Genitourinary system, business.industry, Hazard ratio, neuroendocrine carcinoma, Cancer, ORIGINAL ARTICLE: Neuroendocrine Tumors, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Chemotherapy regimen, Confidence interval, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, Ki67, medicine.drug |
| الوصف: | Background: Neuroendocrine carcinoma (NEC) is a rare tumor arising from the diffuse neuroendocrine system. Most of these present in the advanced stage and palliative chemotherapy remains the only option. The prognosis remains poor with the standard chemotherapy regimen of platinum and etoposide (EP) providing modest survival benefit. Methods: The study was done for 3 years at a tertiary cancer center in South India. Patients with a diagnosis of metastatic NEC were analyzed for clinical and pathological characteristics. The treatment outcomes and prognostic factors were evaluated using appropriate statistical test. Results: A total of 114 patients of metastatic NEC satisfied the inclusion criteria and were analyzed. Gastrointestinal including hepatobiliary tract (33%) was the most common site of primary disease followed by lung (26%), genitourinary (15%), head and neck (14%), and unknown primary (9%). On analysis of pattern of metastasis, liver (65%) was the most common site followed by bone (54%) and lung (42%). The median overall survival was 11 months with a statistically significant difference between pulmonary and extrapulmonary disease (8 vs. 13 months; P = 0.003). Ki67% value was strongly associated with prognosis (hazard ratio 0.517, 95% confidence interval; 0.318–0.840, P = 0.008) whereas age, sex, and lactate dehydrogenase level did not show any relation with survival. Conclusion: The outcome of advanced NEC with standard chemotherapy remains poor. Larger studies with other therapeutic and novel agents are warranted to improve the treatment outcomes. |
| تدمد: | 2278-4306 2278-330X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706d357a536def5556f0cf45625fdba6 https://doi.org/10.4103/sajc.sajc_176_17 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....706d357a536def5556f0cf45625fdba6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22784306 2278330X |
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