Beta-cell failure rather than insulin resistance is the major cause of abnormal glucose tolerance in Africans: insight from the Africans in America study
| العنوان: | Beta-cell failure rather than insulin resistance is the major cause of abnormal glucose tolerance in Africans: insight from the Africans in America study |
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| المؤلفون: | Elyssa M. Shoup, M. C. Sage Ishimwe, Joon Ha, Lilian Mabundo, Arielle C Patterson, Annemarie Wentzel, Hadi Bagheri, Thomas Hormenu, Arthur Sherman, Anne E. Sumner, Christopher Dubose, Nana H. Osei-Tutu |
| المصدر: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Cardiovascular and Metabolic Risk, diagnosis, Endocrinology, Diabetes and Metabolism, Lipoprotein particle, Diseases of the endocrine glands. Clinical endocrinology, chemistry.chemical_compound, Insulin resistance, prediabetic state, Diabetes mellitus, Internal medicine, Insulin-Secreting Cells, Glucose Intolerance, medicine, Humans, Insulin, Mass index, Prediabetes, medicine.diagnostic_test, Triglyceride, business.industry, developing countries, Middle Aged, RC648-665, medicine.disease, Endocrinology, chemistry, type 2, diabetes mellitus, Homeostatic model assessment, Female, Insulin Resistance, Lipid profile, business |
| الوصف: | IntroductionUncertainties exist on whether the main determinant of abnormal glucose tolerance (Abnl-GT) in Africans is β-cell failure or insulin resistance (IR). Therefore, we determined the prevalence, phenotype and characteristics of Abnl-GT due to β-cell failure versus IR in 486 African-born blacks (male: 64%, age: 38±10 years (mean±SD)) living in America.Research design and methodsOral glucose tolerance test were performed. Abnl-GT is a term which includes both diabetes and prediabetes and was defined as fasting plasma glucose (FPG) ≥5.6 mmol/L and/or 2-hour glucose ≥7.8 mmol/L. IR was defined by the lowest quartile of the Matsuda Index (≤2.98) and retested using the upper quartile of homeostatic model assessment of insulin resistance (HOMA-IR) (≥2.07). Abnl-GT-IR required both Abnl-GT and IR. Abnl-GT-β-cell failure was defined as Abnl-GT without IR. Beta-cell compensation was assessed by the Disposition Index (DI). Fasting lipids were measured. Visceral adipose tissue (VAT) volume was obtained with abdominal CT scan.ResultsThe prevalence of Abnl-GT was 37% (182/486). For participants with Abnl-GT, IR occurred in 38% (69/182) and β-cell failure in 62% (113/182). Compared with Africans with Abnl-GT-IR, Africans with Abnl-GT-β-cell failure had lower body mass index (BMI) (30.8±4.3 vs 27.4±4.0 kg/m2), a lower prevalence of obesity (52% vs 19%), less VAT (163±72 vs 107±63 cm2), lower triglyceride (1.21±0.60 vs 0.85±0.42 mmol/L) and lower FPG (5.9±1.4 vs 5.3±0.6 mmol/L) and 2-hour glucose concentrations (10.0±3.1 vs 9.0±1.9 mmol/L) (all pConclusionsBeta-cell failure occurred in two-thirds of participants with Abnl-GT and may be a more frequent determinant of Abnl-GT in Africans than IR. As BMI category, degree of glycemia and lipid profile appeared more favorable when Abnl-GT was due to β-cell failure rather than IR, the clinical course and optimal interventions may differ.Trial registration numberNCT00001853. |
| تدمد: | 2052-4897 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a65254465b247ac8d6e704c8a3724f https://pubmed.ncbi.nlm.nih.gov/34531244 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....70a65254465b247ac8d6e704c8a3724f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 |
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