The Glomerular Filtration Rate Estimators in the Pharmacokinetic Modelling in Acute Kidney Injury: An Observational Study
| العنوان: | The Glomerular Filtration Rate Estimators in the Pharmacokinetic Modelling in Acute Kidney Injury: An Observational Study |
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| المؤلفون: | Vaidotas Galaune, Astra Vitkauskiene, Silvijus Abramavicius, Romaldas Mačiulaitis, Gintautas Gumbrevičius, Agile Tunaityte, Aurelija Radzeviciene |
| المصدر: | Antibiotics Volume 10 Issue 2 Antibiotics, Vol 10, Iss 158, p 158 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), medicine.medical_specialty, Population, 030232 urology & nephrology, Urology, Renal function, 030204 cardiovascular system & hematology, urologic and male genital diseases, Biochemistry, Microbiology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, creatinine clearance, medicine, Pharmacology (medical), Dosing, General Pharmacology, Toxicology and Pharmaceutics, education, reproductive and urinary physiology, Creatinine, education.field_of_study, glomerular filtration rate, estimation, business.industry, urogenital system, lcsh:RM1-950, Acute kidney injury, medicine.disease, female genital diseases and pregnancy complications, Infectious Diseases, lcsh:Therapeutics. Pharmacology, Drug development, chemistry, acute kidney injury, business, Kidney disease |
| الوصف: | The glomerular filtration rate (GFR), according to which the drug dose for patients with chronic kidney disease (CKD) is adjusted, is computed with estimators (eGFR) that are developed specifically for CKD. These particular types of estimators are also used in population pharmacokinetic (pop PK) modelling in drug development. Similar approaches without scientific validation have been proposed for patients with acute kidney injury (AKI), yet it is uncertain which specific eGFR should be used for drug dosing or in pop PK models in patients with AKI. In our study, we included 34 patients with AKI and vancomycin (VCM) treatment, and we built both individual PK and pop PK (non-linear mixed-effects, one-compartment) models to see which eGFR estimator is the best covariate. In these models different eGFRs (Cockcroft-Gault, MDRD, CKD-EPI 2009, Jelliffe and Jelliffe, Chen et al., and Yashiro et al. 2013) were used. We included six additional patients to validate the final pop PK model. All eGFRs underrate the true renal clearance in the AKI, so we created pop PK models for VCM dosing in AKI with all eGFRs, to discover that the most accurate model was the one with the Cockcroft-Gault estimator. Since the eGFRs underestimate the true renal clearance in AKI, they are inaccurate for clinical drug dosing decisions, with the exception of the Cockcroft-Gault one, which is appropriate for the pop PK models intended for drug development purposes in AKI. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-6382 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ca54d5a7f67161490b0fbe70d9e904 http://europepmc.org/articles/PMC7915939 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....70ca54d5a7f67161490b0fbe70d9e904 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20796382 |
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