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No evidence for progressive deterioration in stimulated insulin secretion in renal transplant recipients after 12years tacrolimus exposure

التفاصيل البيبلوغرافية
العنوان: No evidence for progressive deterioration in stimulated insulin secretion in renal transplant recipients after 12years tacrolimus exposure
المؤلفون: M. Gelens, Len A. Usvyat, Johannes P. van Hooff, Maarten H. L. Christiaans
المساهمون: MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Interne Geneeskunde, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting
المصدر: Journal of Diabetes and Its Complications, 31(9), 1384-1388. Elsevier Science
سنة النشر: 2017
مصطلحات موضوعية: Male, Time Factors, Endocrinology, Diabetes and Metabolism, 030232 urology & nephrology, 030230 surgery, 0302 clinical medicine, Endocrinology, Insulin-Secreting Cells, Insulin Secretion, Insulin, Tacrolimus (Tac), Longitudinal Studies, education.field_of_study, GLUCOSE-METABOLISM, Middle Aged, Post transplantation diabetes mellitus (PTDM), Renal transplant, Disease Progression, Female, Immunosuppressive Agents, Adult, medicine.medical_specialty, Population, Carbohydrate metabolism, Tacrolimus, 03 medical and health sciences, Young Adult, Insulin resistance, BETA-CELL FUNCTION, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Beta (finance), Insulin secretion, education, Aged, business.industry, Renal transplantation, Glucose Tolerance Test, medicine.disease, Kidney Transplantation, Transplant Recipients, Cross-Sectional Studies, NODAT, Insulin Resistance, business
الوصف: Aims: Tacrolimus (Tac) inhibits insulin secretion in a Tac-trough blood level dependent way early post-transplant in renal transplant recipients (Rtx). It is unknown whether long-term exposure results into a progressive beta cells dysfunction.Methods: Two independent cohorts of Tac-treated non-diabetic Rtx, previously participating in glucose metabolism studies using intravenous Glucose Tolerance Test (ivGTT) were included: Fifty-eight Rtx were tested by ivGTT cross-sectional between 025 and 12.6 years post-transplant. Factors related to glucose metabolism parameters were explored by multilinear regression analysis. Eighteen non-diabetic Rtx tested by ivGTT 6 months post-transplant were retested at 12 years. The glucose metabolism outcome parameters were also adjusted according to the results of the cross-sectional study.Results: Multivariate analysis showed 'Age', 'BMI' and 'use of steroids' to be significantly related, in different combinations, to the glucose metabolism parameters 'insulin resistance', fasting insulin level' and 'stimulated insulin secretion'. However 'time on tacrolimus' wasn't related to any parameter. In the longitudinal study, none of the glucose metabolism parameters (either analyzed crude or adjusted) deteriorated clinically or statistically significant. Numerically, 'stimulated insulin secretion' even increased.Conclusions: Chronic Tac exposure does NOT lead to a progressive decrease in 'stimulated insulin secretion' between 6 months and 12 years post renal transplant in our population of 18 patients. (C) 2017 Elsevier Inc. All rights reserved.
تدمد: 1873-460X
1056-8727
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d3003f1ce330795d59412d940b7640
https://pubmed.ncbi.nlm.nih.gov/28720321
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....70d3003f1ce330795d59412d940b7640
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1873460X
10568727