Regeneration of skin appendages and nerves: current status and further challenges
| العنوان: | Regeneration of skin appendages and nerves: current status and further challenges |
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| المؤلفون: | Yurong Zheng, Pan Wu, Songxue Guo, Xingang Wang, Ronghua Jin, Haojiao Chen, Chuangang You, Qiong Li, Tingting Weng, Wei Zhang, Chunmao Han |
| المصدر: | Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020) Journal of Translational Medicine |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Medicine, Review, Regenerative medicine, General Biochemistry, Genetics and Molecular Biology, Neural regeneration, 03 medical and health sciences, 0302 clinical medicine, Tissue engineering, Humans, Medicine, Skin appendages, Skin, Neurons, Appendage, Skin repair, Hair follicle, Wound Healing, integumentary system, business.industry, Regeneration (biology), lcsh:R, Chronic pain, General Medicine, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Quality of Life, business, Neuroscience, 030217 neurology & neurosurgery, Sensory nerve |
| الوصف: | Tissue-engineered skin (TES), as an analogue of native skin, is promising for wound repair and regeneration. However, a major drawback of TES products is a lack of skin appendages and nerves to enhance skin healing, structural integrity and skin vitality. Skin appendages and nerves are important constituents for fully functional skin. To date, many studies have yielded remarkable results in the field of skin appendages reconstruction and nerve regeneration. However, patients often complain about a loss of skin sensation and even cutaneous chronic pain. Restoration of pain, temperature, and touch perceptions should now be a major challenge to solve in order to improve patients’ quality of life. Current strategies to create skin appendages and sensory nerve regeneration are mainly based on different types of seeding cells, scaffold materials, bioactive factors and involved signaling pathways. This article provides a comprehensive overview of different strategies for, and advances in, skin appendages and sensory nerve regeneration, which is an important issue in the field of tissue engineering and regenerative medicine. |
| اللغة: | English |
| تدمد: | 1479-5876 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e5e9ad81def5d6b0b1410ee2fa2e27 https://doaj.org/article/7dcfedb843f94b98a6a8b549a42212f9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....70e5e9ad81def5d6b0b1410ee2fa2e27 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14795876 |
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