Influence of Microalbuminuria on Long-Term Survival and Cardiovascular or Limb Events in Peripheral Arterial Disease
العنوان: | Influence of Microalbuminuria on Long-Term Survival and Cardiovascular or Limb Events in Peripheral Arterial Disease |
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المؤلفون: | Akiko Ichikawa, Kuniki Nakashima, Kimimasa Sakata, Toshiya Iwasaki, Ryuichi Funada, Shuichi Ichikawa, Yae Matsuo, Hisao Kumakura |
المصدر: | Annals of Vascular Diseases |
سنة النشر: | 2021 |
مصطلحات موضوعية: | medicine.medical_specialty, Serum albumin, Renal function, urologic and male genital diseases, Internal medicine, Diabetes mellitus, Medicine, cardiovascular diseases, Prospective cohort study, urinary microalbumin, events of leg, biology, business.industry, Cerebral infarction, General Medicine, Critical limb ischemia, medicine.disease, mortality, major adverse cardiovascular events, Cardiology, biology.protein, Microalbuminuria, Original Article, medicine.symptom, business, Mace |
الوصف: | Objective: This study aimed to examine the relationship between microalbuminuria and long-term life expectancy or limb events in patients with peripheral arterial disease (PAD). Materials and Methods: A prospective cohort study was performed in 714 patients with PAD. The primary outcomes were cardiovascular or cerebrovascular death (CCVD) and all-cause death (AD), and secondary outcomes were major adverse cardiovascular events (MACE) and cardiovascular and/or limb events (CVLE). Results: The 5, 10, and 15 year survival rates were 82.4%, 53.1%, and 33.0%, respectively. The prevalence of patients with increased microalbuminuria was 39.2%. Higher microalbuminuria, age, C-reactive protein (CRP), lower serum albumin, estimated glomerular filtration rate (eGFR), ankle-brachial pressure index (ABI), diabetes, cerebral infarction, and coronary heart disease (CHD) were associated with CCVD; higher microalbuminuria, age, CRP, D-dimer, lower serum albumin, eGFR, and critical limb ischemia were related to AD; higher microalbuminuria, age, CRP, lower serum albumin, ABI, diabetes, and CHD were related to MACE; higher microalbuminuria, age, lower ABI, cerebral infarction, and CHD were related to CVLE in Cox multivariate analyses (p |
تدمد: | 1881-641X |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ecf8a9abf8728e04f91845259d0c36 https://pubmed.ncbi.nlm.nih.gov/34707745 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....70ecf8a9abf8728e04f91845259d0c36 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 1881641X |
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