Shigellosis in adults: A retrospective study of clinical and epidemiological features in East London
| العنوان: | Shigellosis in adults: A retrospective study of clinical and epidemiological features in East London |
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| المؤلفون: | Robert Serafino-Wani, Amy Mikhail, Martin Day, Emma McGuire, Gauri Godbole |
| المصدر: | International Journal of STD & AIDS. 30:1373-1381 |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Shigellosis, medicine.medical_specialty, Adolescent, medicine.drug_class, Antibiotics, Prevalence, Microbial Sensitivity Tests, Dermatology, Drug resistance, medicine.disease_cause, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, London, Epidemiology, medicine, Humans, Pharmacology (medical), Shigella, 030212 general & internal medicine, Aged, Dysentery, Bacillary, Retrospective Studies, Aged, 80 and over, 0303 health sciences, Whole Genome Sequencing, 030306 microbiology, business.industry, Public Health, Environmental and Occupational Health, Dysentery, Drug Resistance, Microbial, Retrospective cohort study, Middle Aged, medicine.disease, Anti-Bacterial Agents, Hospitalization, Infectious Diseases, Female, business |
| الوصف: | Shigella is a leading cause of gastroenteritis worldwide; however, data on clinical outcomes amongst adults are lacking. All adult cases (>16 years) of Shigella gastroenteritis diagnosed between January 2014 to December 2017 at an East London NHS Trust in the United Kingdom were included. Demographic, clinical, microbiological and whole genome sequencing (WGS) data were retrospectively collected. Shigella spp isolates from 169 cases were identified: S. flexneri 90 (53.3%), S. sonnei 75 (44.9%) and S. boydii 4 (2.0%). The median age was 34 years (IQR 29–45), and 127 (75.1%) were male. S. flexneri cases were more likely to attend accident and emergency (46.7% vs. 25.3%, p = 0.005), be admitted to hospital (26.7% vs. 10.7%, p = 0.01), and receive antibiotics (51.1% vs. 28.0%, p = 0.003) compared to S. sonnei cases. Thirty-two (18.9%) patients were admitted to hospital for a median of five days (IQR 3–8). Where recorded 42/84 (50.0%) reported recent travel. Seventeen (10.1%) patients experienced complications. There were no deaths within one year of diagnosis. Seventy-nine isolates were characterised by WGS. Fifty-seven (72.2%) belonged to known national clusters; 44 (55.7%) involving adult males and 11 (13.9%) travel-associated clusters. We demonstrate the development of severe complications of shigellosis among adults and highlight the changing epidemiology and antibiotic resistance patterns. |
| تدمد: | 1758-1052 0956-4624 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710348d5e2be47fb84ca97700c59ff41 https://doi.org/10.1177/0956462419871851 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....710348d5e2be47fb84ca97700c59ff41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17581052 09564624 |
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