Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service
| العنوان: | Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service |
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| المؤلفون: | Sherry Krawitz, Shawna Noy, Marc R. Del Bigio |
| المصدر: | Journal of Neuropathology & Experimental Neurology. 75:1145-1154 |
| بيانات النشر: | Oxford University Press (OUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Pathology, Adolescent, Encephalopathy, Population, Autopsy, Neuropathology, Chronic Traumatic Encephalopathy, Pathology and Forensic Medicine, Young Adult, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Concussion, medicine, Humans, Medical history, Prospective Studies, education, education.field_of_study, business.industry, Head injury, Brain, General Medicine, Middle Aged, medicine.disease, Chronic traumatic encephalopathy, 030104 developmental biology, Neurology, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Chronic traumatic encephalopathy (CTE) has been described mainly in professional athletes and military personnel and is characterized by deposition of hyperphosphorylated tau at the depths of cortical sulci and around blood vessels. To assess CTE-like changes in a routine neuropathology service, we prospectively examined 111 brains (age 18-60 years). The presence of tau-immunoreactive deposits was staged using guidelines described by others and was correlated with the medical history. 72/111 cases were negative for CTE-like changes; 34/111 were CTE stage1; 3/111 were CTE stage 1; and 2/111 were CTE stage 2. The combined history of head injury and alcohol and/or drug abuse was a significant predictor of any CTE-like changes. Age was also a significant predictor; most with any CTE-like changes were40 years old. CTE-like changes were not identified at sites of contusion. Among a separate group studied retrospectively, we identified 4 cases that met full criteria for CTE. We conclude that CTE-like findings are not confined to professional athletes; the risk factors of head injury and substance abuse are similar in the routine population. However, the significance of very small hyperphosphorylated tau deposits remains to be determined. In addition, the absence of typical CTE-like deposits near contusion sites keeps open the question of pathogenesis. |
| تدمد: | 1554-6578 0022-3069 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71049b4beb0f06f50e9be612c7ae9877 https://doi.org/10.1093/jnen/nlw092 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....71049b4beb0f06f50e9be612c7ae9877 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15546578 00223069 |
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