Case study on screening emerging pollutants in urine and nails
| العنوان: | Case study on screening emerging pollutants in urine and nails |
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| المؤلفون: | Pim E.G. Leonards, Line Småstuen Haug, Ulrika Nilsson, Adrian Covaci, Cynthia A. de Wit, Griet Jacobs, Claudio Erratico, Luisa Lucattini, Jörgen Magnér, Georgios Giovanoulis, Andreia Alves, Stefan Voorspoels |
| المساهمون: | E&H: Environmental Bioanalytical Chemistry, AIMMS |
| المصدر: | Environmental science and technology Environmental Science and Technology, 51(7), 4046-4053. American Chemical Society Alves, A, Giovanoulis, G, Nilsson, U, Erratico, C, Lucattini, L, Haug, L S, Jacobs, G, De Wit, C A, Leonards, P E G, Covaci, A, Magner, J & Voorspoels, S 2017, ' Case Study on Screening Emerging Pollutants in Urine and Nails ', Environmental Science and Technology, vol. 51, no. 7, pp. 4046-4053 . https://doi.org/10.1021/acs.est.6b05661 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Urine, 010501 environmental sciences, 01 natural sciences, Mass Spectrometry, Matrix (chemical analysis), chemistry.chemical_compound, Plasticizers, Adipate, Environmental Chemistry, Humans, Acetyltributyl Citrate, Biology, 0105 earth and related environmental sciences, Flame Retardants, Chromatography, 010401 analytical chemistry, Plasticizer, Phthalate, Primary metabolite, General Chemistry, 0104 chemical sciences, Chemistry, chemistry, Nails, 13. Climate action, DPHP, Environmental Pollutants, Environmental Monitoring |
| الوصف: | Alternative plasticizers and flame retardants (FRs) have been introduced as replacements for banned or restricted chemicals, but much is still unknown about their metabolism and occurrence in humans. We identified the metabolites formed in vitro for four alternative plasticizers (acetyltributyl citrate (ATBC), bis(2-propylheptyl) phthalate (DPHP), bis(2-ethylhexyl) terephthalate (DEHTP), bis(2ethylhexyl) adipate (DEHA)), and one FR (2,2-bis (chloromethyl)-propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate (V6)). Further, these compounds and their metabolites were investigated by LC/ESI-Orbitrap-MS in urine and finger nails collected from a Norwegian cohort. Primary and secondary ATBC metabolites had detection frequencies (% DF) in finger nails ranging from 46 to 95%. V6 was identified for the first time in finger nails, suggesting that this matrix may also indicate past exposure to FRs as well as alternative plasticizers. Two isomeric forms of DEHTP primary metabolite were highly detected in urine (97% DF) and identified in finger nails, while no DPHP metabolites were detected in vivo. Primary and secondary DEHA metabolites were identified in both matrices, and the relative proportion of the secondary metabolites was higher in urine than in finger nails; the opposite was observed for the primary metabolites. As many of the metabolites present in in vitro extracts were further identified in vivo in urine and finger nail samples, this suggests that in vitro assays can reliably mimic the in vivo processes. Finger nails may be a useful noninvasive matrix for human biomonitoring of specific organic contaminants, but further validation is needed. |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 0013-936X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710ba79c58bf6adc45c858c46891ba84 https://hdl.handle.net/10067/1423950151162165141 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....710ba79c58bf6adc45c858c46891ba84 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 0013936X |
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