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Real world data on clinical profile, management and outcomes of venous thromboembolism from a tertiary care centre in India

التفاصيل البيبلوغرافية
العنوان: Real world data on clinical profile, management and outcomes of venous thromboembolism from a tertiary care centre in India
المؤلفون: Vasu Bansal, Gurpreet Singh Wander, Bhupinder Singh, Bishav Mohan, Gurbhej Singh, Rohit Tandon, Naved Aslam, Sonaal Singla, Tanvi Singla, Shibba Takkar Chhabra, Samir Kapoor, Abhishek Goyal, S. D. Singh
المصدر: Indian Heart Journal
Indian Heart Journal, Vol 73, Iss 3, Pp 336-341 (2021)
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Adult, medicine.medical_specialty, Multivariate analysis, RD1-811, Referral, India, 030204 cardiovascular system & hematology, Malignancy, Tertiary care, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Diseases of the circulatory (Cardiovascular) system, Humans, cardiovascular diseases, 030212 general & internal medicine, Outcome, business.industry, Anticoagulants, Venous Thromboembolism, Middle Aged, medicine.disease, Management, Pulmonary embolism, medicine.anatomical_structure, RC666-701, Cohort, Upper limb, Surgery, Original Article, Pulmonary Embolism, Cardiology and Cardiovascular Medicine, business, Venous thromboembolism
الوصف: Objectives Venous thromboembolism (VTE) is a major cause of mortality and morbidity worldwide. This study describes a real-world scenario of VTE presenting to a tertiary care hospital in India. Methods All patients presenting with acute VTE or associated complications from January 2017 to January 2020 were included in the study. Results A total of 330 patient admissions related to VTE were included over 3 years, of which 303 had an acute episode of VTE. The median age was 50 years (IQR 38–64); 30% of patients were younger than 40 years of age. Only 24% of patients had provoked VTE with recent surgery (56%) and malignancy (16%) being the commonest risk factors. VTE manifested as isolated DVT (56%), isolated pulmonary embolism (PE; 19.1%), combined DVT/PE (22.4%), and upper limb DVT (2.3%). Patients with PE (n = 126) were classified as low-risk (15%), intermediate-risk (55%) and high-risk (29%). Reperfusion therapy was performed for 15.7% of patients with intermediate-risk and 75.6% with high-risk PE. In-hospital mortality for the entire cohort was 8.9%; 35% for high-risk PE and 11% for intermediate-risk PE. On multivariate analysis, the presence of active malignancy (OR = 5.8; 95% CI: 1.1–30.8, p = 0.038) and high-risk PE (OR = 4.8; 95% CI: 1.6–14.9, p = 0.006) were found to be independent predictors of mortality. Conclusion Our data provides real-world perspectives on the demographic sand management of patients presenting with acute VTE in a referral hospital setting. We observed relatively high mortality for intermediate-risk PE, necessitating better subclassification of this group to identify candidates for more aggressive approaches.
تدمد: 0019-4832
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711fa90f459b77693c5b8321c7771edf
https://doi.org/10.1016/j.ihj.2021.02.006
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....711fa90f459b77693c5b8321c7771edf
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00194832