Prognostic implications of left ventricular myocardial work indices in cardiac amyloidosis
| العنوان: | Prognostic implications of left ventricular myocardial work indices in cardiac amyloidosis |
|---|---|
| المؤلفون: | Sara Rosengren, Jens Sörensen, Frank A. Flachskampf, Fabian Mikkelsen, Sven-Olof Granstam, Hans Eiskjær, Bertil Ladefoged, Steen Hvitfeldt Poulsen, Tor Skibsted Clemmensen |
| المصدر: | Clemmensen, T S, Eiskjær, H, Ladefoged, B, Mikkelsen, F, Sørensen, J, Granstam, S-O, Rosengren, S, Flachskampf, F A & Poulsen, S H 2021, ' Prognostic implications of left ventricular myocardial work indices in cardiac amyloidosis ', European Heart Journal Cardiovascular Imaging, vol. 22, no. 6, pp. 695-704 . https://doi.org/10.1093/ehjci/jeaa097 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Speckle tracking echocardiography, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Sweden, business.industry, Myocardium, Hazard ratio, Amyloidosis, General Medicine, Prognosis, medicine.disease, University hospital, Confidence interval, Cardiac amyloidosis, Heart failure, Cardiology, Cardiology and Cardiovascular Medicine, business, Outcome prediction, Mace |
| الوصف: | Aims Left ventricular (LV) myocardial work index (LVMWI) derived from pressure–strain analysis resembles a novel non-invasive method for LV function evaluation. LV global longitudinal strain (LVGLS) has proven beneficial for risk stratification in cardiac amyloidosis (CA) patients. This study aimed to evaluate the potential additive value of LVMWI for outcome prediction in CA patients. Methods and results We enrolled 100 CA patients in the period 2014–19 from Aarhus University Hospital, Denmark and Uppsala University Hospital, Sweden. All patients underwent comprehensive echocardiographic evaluation and were prospectively followed until censuring date on 31 March 2019 or death. During follow-up, we registered major adverse cardiac events (MACE) comprising heart failure requiring hospitalization and all-cause mortality. The median follow-up was 490 (228–895) days. During follow-up, a total of 42% of patients experienced MACE and 29% died. Patients with LVMWI 1043 mmHg% [hazard ratio (HR) 2.3, 95% confidence interval (CI) 1.2–4.3; P = 0.01]. Furthermore, patients with LVMWI 1039 mmHg% (HR 2.6, 95% CI 1.2–5.5; P Conclusion LV myocardial work may be of prognostic value in CA patients by predicting both MACE and all-cause mortality. |
| تدمد: | 2047-2412 2047-2404 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71736042acce963bfd6c418ca09f8d4f https://doi.org/10.1093/ehjci/jeaa097 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....71736042acce963bfd6c418ca09f8d4f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472412 20472404 |
|---|