Hippocampal Complex Atrophy in Poststroke and Mild Cognitive Impairment
| العنوان: | Hippocampal Complex Atrophy in Poststroke and Mild Cognitive Impairment |
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| المؤلفون: | Atle Bjørnerud, Krisztina Kunszt Johansen, Ina S. Almdahl, Börje Bjelke, Mariano Rincón, Eirik Auning, Erik Hessen, Leif Gjerstad, Paulina Due-Tønnessen, Ramune Grambaite, Per Selnes, Tormod Fladby, Kjetil Vegge |
| المصدر: | Journal of Cerebral Blood Flow & Metabolism. 35:1729-1737 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Hippocampus, tau Proteins, Neuropsychological Tests, Hippocampal formation, behavioral disciplines and activities, White matter, Executive Function, Atrophy, Alzheimer Disease, Memory, Internal medicine, mental disorders, Reaction Time, medicine, Humans, Cognitive Dysfunction, Stroke, Aged, Aged, 80 and over, Amyloid beta-Peptides, medicine.diagnostic_test, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, White Matter, Hyperintensity, Cerebrovascular Disorders, medicine.anatomical_structure, Neurology, Mental Recall, Cardiology, Female, Original Article, Neurology (clinical), Alzheimer's disease, Cardiology and Cardiovascular Medicine, Psychology, Neuroscience, Psychomotor Performance |
| الوصف: | To investigate putative interacting or distinct pathways for hippocampal complex substructure (HCS) atrophy and cognitive affection in early-stage Alzheimer's disease (AD) and cerebrovascular disease (CVD), we recruited healthy controls, patients with mild cognitive impairment (MCI) and poststroke patients. HCSs were segmented, and quantitative white-matter hyperintensity (WMH) load and cerebrospinal fluid (CSF) amyloid-β concentrations were determined. The WMH load was higher poststroke. All examined HCSs were smaller in amyloid-positive MCI than in controls, and the subicular regions were smaller poststroke. Memory was reduced in amyloid-positive MCI, and psychomotor speed and executive function were reduced in poststroke and amyloid-positive MCI. Size of several HCS correlated with WMH load poststroke and with CSF amyloid-β concentrations in MCI. In poststroke and amyloid-positive MCI, neuropsychological function correlated with WMH load and hippocampal volume. There are similar patterns of HCS atrophy in CVD and early-stage AD, but different HCS associations with WMH and CSF biomarkers. WMHs add to hippocampal atrophy and the archetypal AD deficit delayed recall. In line with mounting evidence of a mechanistic link between primary AD pathology and CVD, these additive effects suggest interacting pathologic processes. |
| تدمد: | 1559-7016 0271-678X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71893f8dc3ede99a03dd7e157530c4ac https://doi.org/10.1038/jcbfm.2015.110 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....71893f8dc3ede99a03dd7e157530c4ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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