Epidemiology of Methicillin-SusceptibleStaphylococcus Aureusin the Neonatal Intensive Care Unit
| العنوان: | Epidemiology of Methicillin-SusceptibleStaphylococcus Aureusin the Neonatal Intensive Care Unit |
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| المؤلفون: | Juyan Zhou, Anne-Sophie Morel, David Rubenstein, Phyllis Della-Latta, Fann Wu, Lisa Saiman, Philip L. Graham |
| المصدر: | Infection Control & Hospital Epidemiology. 23:677-682 |
| بيانات النشر: | Cambridge University Press (CUP), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Microbiology (medical), Staphylococcus aureus, Pediatrics, medicine.medical_specialty, Neonatal intensive care unit, Epidemiology, Mupirocin, law.invention, Cohort Studies, chemistry.chemical_compound, Risk Factors, law, Intensive Care Units, Neonatal, Humans, Infection control, Medicine, Electrophoresis, Gel, Two-Dimensional, Risk factor, Retrospective Studies, Antibacterial agent, Cross Infection, Molecular Epidemiology, business.industry, Incidence, Incidence (epidemiology), Infant, Newborn, Staphylococcal Infections, Intensive care unit, Anterior nares, Infectious Diseases, medicine.anatomical_structure, chemistry, Methicillin Resistance, New York City, business, Sentinel Surveillance |
| الوصف: | Objective:When the incidence of methicillin-susceptibleStaphylococcus aureus(MSSA) infection or colonization increased in our neonatal intensive care unit (NICU), we sought to further our understanding of the relationship among colonization with MSSA, endemic infection, and clonal spread.Design:A retrospective cohort study was used to determine risk factors for acquisition of a predominant clone of MSSA (clone “B”).Setting:A 45-bed, university-affiliated, level III-IV NICU.Patients:Infants hospitalized in the NICU from October 1999 to September 2000.Interventions:Infection control strategies included surveillance cultures of infants, cohorting infected or colonized infants, contact precautions, universal glove use, mupirocin treatment of the anterior nares of all infants in the NICU, and a hexachlorophene bath for infants weighing 1,500 g or more.Results:During the 1-year study period, three periods of increased incidence of MSSA colonization or infection, ranging from 6.4 to 13.5 cases per 1,000 patient-days per month, were observed. Molecular typing using pulsed-field gel electrophoresis demonstrated two predominant clones, clone “B” and clone “G,” corresponding to two periods of increased incidence. Multivariate analysis demonstrated that length of stay (OR, 1.035; 95% confidence interval [CI95], 1.008 to 1.062;P= .010) (increased risk per day) and the use of H2-blockers (OR, 20.44; CI95, 2.48 to 168.26;P= .005) were risk factors for either colonization or infection with clone “B,” and that the use of peripheral catheters was protective (OR, 0.06; CI95, 0.01 to 0.43;P= .005).Conclusions:Control of MSSA represents unique challenges as colonization is expected, endemic infections are tolerated, and surveillance efforts generally focus on multidrug-resistant pathogens. Future studies should address cost-effective surveillance strategies for endemic infections. |
| تدمد: | 1559-6834 0899-823X 0195-9417 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a25dd6ad73b146d44bd2169ec646e2 https://doi.org/10.1086/501993 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....71a25dd6ad73b146d44bd2169ec646e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15596834 0899823X 01959417 |
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