Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives
| العنوان: | Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives |
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| المؤلفون: | Chaojun Tang, Lei Wang |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 9760, p 9760 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Platelets, Inflammation, Disease, Review, 030204 cardiovascular system & hematology, Catalysis, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Hyperlipidemia, medicine, Animals, Humans, hyperlipidemia, Platelet, Physical and Theoretical Chemistry, Receptor, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, platelet, business.industry, Organic Chemistry, atherogenesis, General Medicine, medicine.disease, Thrombosis, Plaque, Atherosclerotic, Computer Science Applications, 030104 developmental biology, disturbed flow, lcsh:Biology (General), lcsh:QD1-999, inflammation, Hemostasis, Immunology, platelet migration, Disturbed flow, hyperglycemia, medicine.symptom, business |
| الوصف: | Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites under disturbed blood flow with low speeds and chaotic directions. Hyperglycemia, hyperlipidemia, and hypertension are all risk factors for atherosclerosis. When the vascular microenvironment changes, platelets can respond quickly to interact with endothelial cells and leukocytes, participating in atherosclerosis. This review discusses the important roles of platelets in the plaque formation under pro-atherogenic factors. Specifically, we discussed the platelet behaviors under disturbed flow, hyperglycemia, and hyperlipidemia conditions. We also summarized the molecular mechanisms involved in vascular inflammation during atherogenesis based on platelet receptors and secretion of inflammatory factors. Finally, we highlighted the studies of platelet migration in atherogenesis. In general, we elaborated an atherogenic role of platelets and the aspects that should be further studied in the future. |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71def49168266409917e4a503decff86 https://pubmed.ncbi.nlm.nih.gov/33371312 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....71def49168266409917e4a503decff86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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