American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Supplementary Figures 1-9; Supplementary Table 1. Suppl. Fig. 1 Western blotting for downstream targets of PI3K and mTOR. Suppl. Fig. 2 Effect of dual PI3K/mTOR inhibitors on OCR. Suppl. Fig. 3 Effect of BEZ235 on mitochondrial mass and membrane potential. Suppl. Fig. 4 Analysis of the COX1 DNA levels by RT-PCR. Suppl. Fig. 5 Effect of dual PI3K/mTOR inhibitors on PDH complex subunits. Suppl. Fig. 6 Effects on OCR following the treatment with inhibitors of Akt and/or PI3K. Suppl. Fig. 7 Relationship between PI3K activation and PDH-E1α phosphorylation using doxycycline-inducible system. Suppl. Fig. 8 Effect of PDH-E1α inhibition on OCR. Suppl. Fig. 9 Effect of PDH-E1α mutants on PDH-E1α phosphorylation. Table S1 Sequence of primers used to measure the levels of the COX1 and PNC1.
