Repurposing colchicine’s journey in view of drug-to-drug interactions. A review
| العنوان: | Repurposing colchicine’s journey in view of drug-to-drug interactions. A review |
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| المؤلفون: | George Giannopoulos, Michael W. Cleman, Theodore G. Papaioannou, Alexandra J. Lansky, Sotiria G. Giotaki, Gerasimos Siasos, Giulio G. Stefanini, Spyridon Deftereos, Jean-Claude Tardif, Konstantinos A. Papathanasiou, Konstantinos Iliodromitis, Dimitrios A. Vrachatis, Bernhard Reimers |
| المصدر: | Toxicology Reports, Vol 8, Iss, Pp 1389-1393 (2021) Toxicology Reports |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Drug, medicine.medical_specialty, 2019-20 coronavirus outbreak, History, Health, Toxicology and Mutagenesis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, CAD, coronary artery disease, Toxicology, CAD - Coronary artery disease, ACS - Acute coronary syndrome, chemistry.chemical_compound, Lp-PLA2, Lipoprotein-associated phospholipase A2, RA1190-1270, medicine, Colchicine, Pharmacokinetics, Intensive care medicine, Repurposing, media_common, ComputingMethodologies_COMPUTERGRAPHICS, Inflammation, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, business.industry, eGFR, estimated glomerular filtration rate, Toxicology and Redox Biology under the frame of their historical evolution, COVID-19, coronavirus disease - 19, DOACs, direct oral anticoagulants, Clinical Practice, chemistry, ROCK, Rho-associated protein kinase, Toxicology. Poisons, ACS, acute coronary syndrome, Safety, business |
| الوصف: | Graphical abstract Highlights • Colchicine is among the oldest drug molecules in medical history. • Clinicians should always check for drug to drug interactions and modify colchicine’s dose according to published guidelines. • Beyond known indications (e.g. pericarditis, gout), current evidence implies favorable colchicine effects in CAD, stroke and even in COVID19. Colchicine’s medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine’s future potential applications. |
| اللغة: | English |
| تدمد: | 2214-7500 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72213392b99a6a946308446638fc594d http://www.sciencedirect.com/science/article/pii/S2214750021001360 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....72213392b99a6a946308446638fc594d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22147500 |
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