Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI
| العنوان: | Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI |
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| المؤلفون: | Harald Arnesen, Ingebjørg Seljeflot, Shanmuganathan Limalanathan, Miriam Sjåstad Langseth, Ragnhild Helseth, Trine Baur Opstad, Jan Eritsland, Geir Øystein Andersen, Christian Shetelig, Pavel Hoffmann |
| المصدر: | Mediators of Inflammation, Vol 2019 (2019) Mediators of Inflammation |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Article Subject, Immunology, Myocardial Infarction, 030204 cardiovascular system & hematology, Extracellular Traps, 03 medical and health sciences, 0302 clinical medicine, Cardiac magnetic resonance imaging, Internal medicine, medicine, lcsh:Pathology, Humans, Myocardial infarction, cardiovascular diseases, Ventricular remodeling, Aged, Ejection fraction, medicine.diagnostic_test, Troponin T, business.industry, Hazard ratio, Cell Biology, Neutrophil extracellular traps, DNA, Middle Aged, medicine.disease, 030104 developmental biology, Conventional PCI, Cardiology, ST Elevation Myocardial Infarction, Female, business, Research Article, lcsh:RB1-214 |
| الوصف: | Background. The relevance of neutrophil extracellular traps (NETs) in acute ST-elevation myocardial infarction (STEMI) is unclear. We explored the temporal profile of circulating NET markers and their associations to myocardial injury and function and to adverse clinical events in STEMI patients. Methods and Results. In 259 patients, blood samples were drawn before and after PCI, on day 1, and after 4 months. Double-stranded deoxyribonucleic acid (dsDNA) and myeloperoxidase-DNA (MPO-DNA) were measured in serum by a nucleic acid stain and ELISA. Cardiac magnetic resonance imaging assessed microvascular obstruction (MVO), area at risk, infarct size, myocardial salvage index, left ventricular ejection fraction (LVEF), and change in indexed left ventricular end-diastolic volume (LVEDVi). Clinical events were registered after 12 months. dsDNA and MPO-DNA levels were highest before PCI, with reduced levels thereafter (all p≤0.02). Patients with high vs. low day 1 dsDNA levels (>median; 366 ng/ml) more frequently had MVO, larger area at risk, larger infarct size acutely and after 4 months, and lower myocardial salvage index (all p<0.03). Moreover, they had lower LVEF acutely and after 4 months, and larger change in LVEDVi (all p≤0.014). High day 1 dsDNA levels also associated with risk of having a large infarct size (>75th percentile) and low LVEF (≤49%) after 4 months when adjusted for gender, time from symptoms to PCI, and infarct localization (OR 2.3 and 3.0, both p<0.021), and patients with high day 1 dsDNA levels were more likely to experience an adverse clinical event, also when adjusting for peak troponin T (hazard ratio 5.1, p=0.012). No such observations were encountered for MPO-DNA. Conclusions. High day 1 dsDNA levels after STEMI were associated with myocardial infarct size, adverse left ventricular remodeling, and clinical outcome. Although the origin of dsDNA could be discussed, these observations indicate a potential role for dsDNA in acute myocardial ischemia. This trial is registered with S-08421d, 2008/10614 (Regional Committee for Medical Research Ethics in South-East Norway (2008)). |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1466-1861 0962-9351 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723036b412c769d9ce3132736fcd0b53 https://doaj.org/article/2f4099584d30414d8bf3d9f0c8f294a9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....723036b412c769d9ce3132736fcd0b53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14661861 09629351 |
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