Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter
| العنوان: | Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter |
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| المؤلفون: | Sean P. Curran, Hans M. Dalton, Constantinos Sioutas, Farimah Shirmohammadi, Nikoo Safi, Todd E. Morgan, Amin Haghani, Caleb E. Finch |
| المصدر: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences |
| بيانات النشر: | Oxford University Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Aging, Longevity, Air pollution, Gene Expression, Development, medicine.disease_cause, Biological pathway, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cultured cell, Medicine, Animals, Body Size, Caenorhabditis elegans, Caenorhabditis elegans Proteins, 030304 developmental biology, Vehicle Emissions, 0303 health sciences, biology, integumentary system, business.industry, skn-1, Hormesis, nPM, biology.organism_classification, Cell biology, DNA-Binding Proteins, Adult life, chemistry, Worms in Aging Research, 13. Climate action, The Journal of Gerontology: Biological Sciences, Models, Animal, Nanoparticles, Pharynx, Lethality, Particulate Matter, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Toxicant, Transcription Factors |
| الوصف: | Air pollution is a heterogeneous environmental toxicant that impacts humans throughout their life. We introduce Caenorhabditis elegans as a valuable air pollution model with its short lifespan, medium-throughput capabilities, and highly conserved biological pathways that impact healthspan. We exposed developmental and adult life stages of C. elegans to airborne nano-sized particulate matter (nPM) produced by traffic emissions and measured biological and molecular endpoints that changed in response. Acute nPM did not cause lethality in C. elegans, but short-term exposure during larval stage 1 caused delayed development. Gene expression responses to nPM exposure overlapped with responses of mouse and cell culture models of nPM exposure in previous studies. We showed further that the skn-1/Nrf2 antioxidant response has a role in the development and hormetic effects of nPM. This study introduces the worm as a new resource and complementary model for mouse and cultured cell systems to study air pollution toxicity across the lifespan. |
| اللغة: | English |
| تدمد: | 1758-535X 1079-5006 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72414db063461933f7f473f07540c53c http://europepmc.org/articles/PMC6625599 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....72414db063461933f7f473f07540c53c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1758535X 10795006 |
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