Immune Response in Pneumocystis Infections According to the Host Immune System Status
| العنوان: | Immune Response in Pneumocystis Infections According to the Host Immune System Status |
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| المؤلفون: | Xavier Iriart, Eléna Charpentier, Catherine Marques, Sandie Menard, Antoine Berry |
| المساهمون: | Benson-Rumiz, Alicia, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Journal of Fungi Journal of Fungi, 2021, 7 (8), pp.625. ⟨10.3390/jof7080625⟩ Journal of Fungi, Vol 7, Iss 625, p 625 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), QH301-705.5, Lymphocyte, medicine.medical_treatment, 030106 microbiology, Inflammation, Pneumocystis, Plant Science, Review, lymphocyte, Pneumocystis pneumonia, immune response, pneumocystosis, 03 medical and health sciences, TCD4, Immune system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, TCD8, medicine, Macrophage, Biology (General), Ecology, Evolution, Behavior and Systematics, Immunodeficiency, B cells, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, immunosuppression, business.industry, Immunosuppression, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, inflammation, Immunology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine.symptom, Pneumocystis Infections, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience; The host immune response is critical in Pneumocystis pneumonia (PCP). Immunocompetent hosts can eliminate the fungus without symptoms, while immunodeficient hosts develop PCP with an unsuitable excessive inflammatory response leading to lung damage. From studies based on rodent models or clinical studies, this review aimed to better understand the pathophysiology of Pneumocystis infection by analysing the role of immune cells, mostly lymphocytes, according to the immune status of the infected host. Hence, this review first describes the immune physiological response in infected immunocompetent hosts that are able to eliminate the fungus. The objective of the second part is to identify the immune elements required for the control of the fungus, focusing on specific immune deficiencies. Finally, the third part concentrates on the effect of the different immune elements in immunocompromised subjects during PCP, to better understand which cells are detrimental, and which, on the contrary, are beneficial once the disease has started. This work highlights that the immune response associated with a favourable outcome of the infection may differ according to the immune status of the host. In the case of immunocompetency, a close communication between B cells and TCD4 within tertiary lymphocyte structures appears critical to activate M2 macrophages without much inflammation. Conversely, in the case of immunodeficiency, a pro-inflammatory response including Th1 CD4, cytotoxic CD8, NK cells, and IFNγ release seems beneficial for M1 macrophage activation, despite the impact of inflammation on lung tissue. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2309-608X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72482676a1a1d3c4e9a87a725b3abdae http://europepmc.org/articles/PMC8399367 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....72482676a1a1d3c4e9a87a725b3abdae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2309608X |
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