Validation of transcutaneous bilirubin nomogram for identifying neonatal hyperbilirubinemia in healthy Chinese term and late-preterm infants: a multicenter study
| العنوان: | Validation of transcutaneous bilirubin nomogram for identifying neonatal hyperbilirubinemia in healthy Chinese term and late-preterm infants: a multicenter study |
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| المؤلفون: | Huai-Yan Wang, Xinnian Pan, Jinxia Wu, Mingxia Li, Shuping Han, Jimei Wang, Chao Chen, Jie Yang, Jiebo Liu, Zhangbin Yu |
| المصدر: | Jornal de Pediatria v.90 n.2 2014 Jornal de Pediatria Sociedade Brasileira de Pediatria (SBP) instacron:SBPE Jornal de Pediatria, Vol 90, Iss 3, Pp 273-278 (2014) Jornal de Pediatria (Versão em Português), Vol 90, Iss 3, Pp 273-278 (2014) Jornal de Pediatria v.90 n.3 2014 Jornal de Pediatria, Volume: 90, Issue: 3, Pages: 273-278, Published: JUN 2014 Jornal de Pediatria, Volume: 90, Issue: 2, Pages: 273-278, Published: APR 2014 |
| بيانات النشر: | Sociedade Brasileira de Pediatria, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Percentile, China, genetic structures, Icterícia, Jaundice, Gestational Age, Hospitals, Maternity, Hospitals, General, Sensitivity and Specificity, Bilirrubina, Predictive Value of Tests, Pregnancy, Risk Factors, Hiperbilirrubinemia, Neonatal, Late preterm, Medicine, Humans, Prospective Studies, Pediatrics, Perinatology, and Child Health, Neonatos, Hyperbilirubinemia, Transcutaneous bilirubin, business.industry, Area under the curve, Infant, Newborn, lcsh:RJ1-570, lcsh:Pediatrics, Bilirubin, Nomogram, Newborn, Predictive value, Patient Discharge, Nomograms, Multicenter study, Pediatrics, Perinatology and Child Health, Female, Hyperbilirubinemia, Neonatal, business, Clinical risk factor, Infant, Premature, eonatos, Follow-Up Studies |
| الوصف: | Objective: to prospectively validate a previously constructed transcutaneous bilirubin (TcB) nomogram for identifying severe hyperbilirubinemia in healthy Chinese term and late‐preterm infants. Methods: this was a multicenter study that included 9,174 healthy term and late‐preterm infants in eight hospitals of China. TcB measurements were performed using a JM‐103 bilirubinometer. TcB values were plotted on a previously developed TcB nomogram, to identify the predictive ability for subsequent significant hyperbilirubinemia. Results: in the present study, 972 neonates (10.6%) developed significant hyperbilirubinemia. The 40th percentile of the nomogram could identify all neonates who were at risk of significant hyperbilirubinemia, but with a low positive predictive value (PPV) (18.9%). Of the 453 neonates above the 95th percentile, 275 subsequently developed significant hyperbilirubinemia, with a high PPV (60.7%), but with low sensitivity (28.3%). The 75th percentile was highly specific (81.9%) and moderately sensitive (79.8%). The area under the curve (AUC) for the TcB nomogram was 0.875. Conclusions: this study validated the previously developed TcB nomogram, which could be used to predict subsequent significant hyperbilirubinemia in healthy Chinese term and late‐preterm infants. However, combining TcB nomogram and clinical risk factors could improve the predictive accuracy for severe hyperbilirubinemia, which was not assessed in the study. Further studies are necessary to confirm this combination. Resumo: Objetivo: validar de forma prospectiva um nomograma de bilirrubina transcutânea (BTc) para identificar hiperbilirrubinemia grave em neonatos a termo e pré‐termo tardios saudáveis na China. Métodos: foi realizado um estudo multicêntrico que incluiu 9174 neonatos a termo e pré‐termo tardios saudáveis em oito unidades da China. Foram realizadas dosagens de BTc utilizando um bilirrubinômetro. Os valores de BTc foram traçados em um nomograma de BTc para identificar a capacidade de predição de hiperbilirrubinemia significativa. Resultados: 972 recém‐nascidos (10,6%) desenvolveram hiperbilirrubinemia significativa. O percentil 40 de nosso nomograma pode identificar todos os recém‐nascidos com risco de hiperbilirrubinemia significativa, porém com baixo valor preditivo positivo (VPP) (18,9%). De 453 recém‐nascidos acima do percentil 95, 275 recém‐nascidos desenvolveram posteriormente hiperbilirrubinemia significativa, com VPP elevado (60,7%), porém com baixa sensibilidade (28,3%). O percentil de 75 foi altamente específico (81,9%) e moderadamente sensível (79,8%). A área sob a curva (ASC) de nosso nomograma de BTc foi de 0,875. Conclusões: este estudo validou o nomograma de BTc, que pode ser utilizado para prever hiperbilirrubinemia significativa em neonatos a termo e pré‐termo tardios saudáveis na China. Contudo, combinar o nomograma de BTc e fatores de risco clínicos pode melhorar a precisão de predição da hiperbilirrubinemia grave, o que não foi avaliado neste estudo. São necessários estudos adicionais para confirmar essa combinação. Keywords: Hyperbilirubinemia, Jaundice, Neonatal, Bilirubin, Newborn, Palavras‐chave: Hiperbilirrubinemia, Icterícia, Neonatal, Bilirrubina, Neonatos |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727c1ca2e5e4a2343834413eae55a47f http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000200273 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....727c1ca2e5e4a2343834413eae55a47f |
| قاعدة البيانات: | OpenAIRE |
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