Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents
| العنوان: | Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents |
|---|---|
| المؤلفون: | Fabio Colella, Jacopo Oieni, Bernardo P. Antunes, Marco Sorbona, Andrea Lolli, Serdar Capar, Luana Zerrillo, Domenico D'Atri, Yunpeng Cai, J. Garcia, Sonja Häckel, Florian P.Y. Barré, M.L. Vainieri, Laura B. Creemers |
| المساهمون: | Orthopedics and Sports Medicine |
| المصدر: | Colella, F, Garcia, J P, Sorbona, M, Lolli, A, Antunes, B, D'Atri, D, Barré, F P Y, Oieni, J, Vainieri, M L, Zerrillo, L, Capar, S, Häckel, S, Cai, Y & Creemers, L B 2020, ' Drug delivery in intervertebral disc degeneration and osteoarthritis : Selecting the optimal platform for the delivery of disease-modifying agents ', Journal of Controlled Release, vol. 328, pp. 985-999 . https://doi.org/10.1016/j.jconrel.2020.08.041 Colella, Fabio; Garcia, João Pedro; Sorbona, Marco; Lolli, Andrea; Antunes, Bernardo; D'Atri, Domenico; Barré, Florian P Y; Oieni, Jacopo; Vainieri, Maria Letizia; Zerrillo, Luana; Capar, Serdar; Häckel, Sonja; Cai, Yunpeng; Creemers, Laura B (2020). Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents. Journal of controlled release, 328, pp. 985-999. Elsevier 10.1016/j.jconrel.2020.08.041 <http://dx.doi.org/10.1016/j.jconrel.2020.08.041> Journal of Controlled Release, 328, 985-999. ELSEVIER Journal of Controlled Release, 328, 985-999. Elsevier J Control Release |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, Adult, media_common.quotation_subject, Pharmaceutical Science, 610 Medicine & health, 02 engineering and technology, Degeneration (medical), Osteoarthritis, Disease, Intervertebral Disc Degeneration, KNEE OSTEOARTHRITIS, Large animal-model, Bioinformatics, TRIAMCINOLONE ACETONIDE, PLATELET-RICH PLASMA, Low-back-pain, 03 medical and health sciences, Drug Delivery Systems, In-vivo, FIBROBLAST GROWTH FACTOR-18, Biochemical composition, Medicine, Humans, INTRAARTICULAR INJECTION, Intervertebral Disc, 030304 developmental biology, media_common, 0303 health sciences, business.industry, Fibrin/hyaluronic acid hydrogel, Intervertebral disc, 021001 nanoscience & nanotechnology, medicine.disease, medicine.anatomical_structure, Drug concentration, Pharmaceutical Preparations, WNT PATHWAY INHIBITOR, Drug delivery, 0210 nano-technology, business |
| الوصف: | Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic low back pain represent the most common degenerative joint pathologies and are leading causes of pain and disability in adults. Articular cartilage (AC) and intervertebral discs are cartilaginous tissues with a similar biochemical composition and pathophysiological aspects of degeneration. Although treatments directed at reversing these conditions are yet to be developed, many promising disease-modifying drug candidates are currently under investigation. Given the localized nature of these chronic diseases, drug delivery systems have the potential to enhance therapeutic outcomes by providing controlled and targeted release of bioactives, minimizing the number of injections needed and increasing drug concentration in the affected areas. This review provides a comprehensive overview of the currently most promising disease-modifying drugs as well as potential drug delivery systems for OA and IVDD therapy. |
| وصف الملف: | application/pdf |
| تدمد: | 0168-3659 |
| DOI: | 10.48350/149049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b2b3042e1889bd74d8bfb96e174150 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....72b2b3042e1889bd74d8bfb96e174150 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01683659 |
|---|---|
| DOI: | 10.48350/149049 |