Establishing A New Option for Target-organ Protection: Rationale for ARB Plus ACE Inhibitor Combination Therapy
| العنوان: | Establishing A New Option for Target-organ Protection: Rationale for ARB Plus ACE Inhibitor Combination Therapy |
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| المؤلفون: | Jesse Goldman, Jay N. Cohn |
| المصدر: | American Journal of Hypertension. 21:248-256 |
| بيانات النشر: | Oxford University Press (OUP), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Angiotensin Receptor Antagonists, Combination therapy, business.industry, Angiotensin-Converting Enzyme Inhibitors, Pharmacology, medicine.disease, Nephropathy, Renin-Angiotensin System, Pharmacotherapy, Blood pressure, Cardiovascular Diseases, Heart failure, Hypertension, ACE inhibitor, Internal Medicine, medicine, Humans, Drug Therapy, Combination, Kidney Diseases, Dosing, business, Angiotensin II Type 1 Receptor Blockers, medicine.drug |
| الوصف: | Activation of the renin-angiotensin system (RAS) plays an important role in the promotion of cardiovascular disease and target-organ damage, mediated in part by hypertension. Combination therapy targeting RAS activation may reduce target-organ damage and provide superior blood pressure (BP) control; combining angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) represents one possible approach. In monotherapy studies, both ACE inhibitors and ARBs have demonstrated similar positive effects on BP and on RAS-related target-organ damage, including nephropathy and congestive heart failure. Studies of combination therapy, most of which involved addition of an ARB to existing ACE inhibitor therapy, have demonstrated benefits among patients with congestive heart failure and renal disease. However, variances in study design and populations, dosing and titration methods, and clinical end points, in addition to inherent differences between agents, limit the ability to reach clinically meaningful conclusions about the value of dual RAS inhibition. Trials designed to document such efficacy are currently underway. |
| تدمد: | 1941-7225 0895-7061 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730ad0e4001c3ff959b4d4304e7a4d39 https://doi.org/10.1038/ajh.2007.56 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....730ad0e4001c3ff959b4d4304e7a4d39 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19417225 08957061 |
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