Lower bone mineral density and higher bone resorption marker levels in premenopausal women with type 1 diabetes in Japan
| العنوان: | Lower bone mineral density and higher bone resorption marker levels in premenopausal women with type 1 diabetes in Japan |
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| المؤلفون: | Muneto Yoshioka, Fumi Yoshioka, Naoki Sakane, Tomokazu Watanabe, Takashi Murata, Yaeko Kawaguchi, Kunio Saeki, Shinsuke Nirengi |
| المصدر: | Journal of Diabetes Investigation, Vol 12, Iss 9, Pp 1689-1696 (2021) Journal of Diabetes Investigation |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Heel, Endocrinology, Diabetes and Metabolism, Osteoporosis, 030209 endocrinology & metabolism, Tartrate‐resistant acid phosphatase‐5b, Bone resorption, Diseases of the endocrine glands. Clinical endocrinology, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Japan, Type 1 diabetes mellitus, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Bone mineral density, Humans, 030212 general & internal medicine, Bone Resorption, Bone mineral, Type 1 diabetes, business.industry, Articles, General Medicine, Middle Aged, Prognosis, medicine.disease, RC648-665, Postmenopause, Bone Diseases, Metabolic, Diabetes Mellitus, Type 1, Clinical Science and Care, medicine.anatomical_structure, Premenopause, Female, Original Article, Calcaneus, business, Biomarkers, Follow-Up Studies |
| الوصف: | Aims/Introduction Type 1 diabetes is associated with poorer bone quality. Quantitative ultrasound provides an estimate of bone mineral density (BMD) and can also be used to evaluate bone quality, which is associated with an increased fracture risk in people with type 1 diabetes. The aim of this study was to evaluate the association between menopausal status and a bone turnover marker with heel BMD using quantitative ultrasound in women with type 1 diabetes and age‐ and body mass index‐matched controls. Materials and Methods A total of 124 individuals recruited in Kyoto and Osaka, Japan – 62 women with type 1 diabetes (mean age 47.2 ± 17.3 years) and 62 age‐, menopausal status‐, sex‐ and body mass index‐matched non‐diabetic control individuals (mean age 47.3 ± 16.3 years) – were enrolled in this study. Heel BMD in the calcaneus was evaluated using ultrasonography (AOS‐100NW, Hitachi‐Aloka Medical, Ltd., Tokyo, Japan). A bone turnover marker was also measured. Results The heel BMD Z‐score was significantly lower in premenopausal women with type 1 diabetes than in the premenopausal control group, but not in postmenopausal women with type 1 diabetes. Levels of tartrate‐resistant acid phosphatase‐5b, a bone resorption marker, were significantly higher in premenopausal women with type 1 diabetes than in the premenopausal control group, but not in postmenopausal women with type 1 diabetes. The whole parathyroid hormone level was significantly lower in both pre‐ and postmenopausal women with type 1 diabetes. Conclusions Lower heel BMD, higher tartrate‐resistant acid phosphatase‐5b level and lower parathyroid hormone were observed in premenopausal women with type 1 diabetes. Premenopausal women with type 1 diabetes require osteoporosis precautions for postmenopause. |
| اللغة: | English |
| تدمد: | 2040-1116 2040-1124 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73133ae0033e4e07c0cadd636882b138 https://doaj.org/article/fbe0f23e15154ca3bc2388a75b425908 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....73133ae0033e4e07c0cadd636882b138 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401116 20401124 |
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