Revelation of the Balanol Biosynthetic Pathway in Tolypocladium ophioglossoides
| العنوان: | Revelation of the Balanol Biosynthetic Pathway in Tolypocladium ophioglossoides |
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| المؤلفون: | Xian He, Yuan-Yang Guo, Xu-Ming Mao, Xin-Ai Chen, Yong-Quan Li, Min Zhang |
| المصدر: | Organic Letters. 20:6323-6326 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Metabolite, 010402 general chemistry, 01 natural sciences, Biochemistry, Balanol, chemistry.chemical_compound, Metabolomics, Biosynthesis, Gene cluster, Hydroxybenzoates, Physical and Theoretical Chemistry, Gene, Tolypocladium ophioglossoides, biology, 010405 organic chemistry, Organic Chemistry, Azepines, biology.organism_classification, Biosynthetic Pathways, 0104 chemical sciences, chemistry, Multigene Family, Hypocreales, Genome mining |
| الوصف: | A cryptic gene cluster, bln, was activated by genome mining in Tolypocladium ophioglossoides. This activation led to the production of balanol and eight other metabolites. Gene disruption and metabolite profile analysis showed that the biosynthesis of balanol involved the convergence of independent PKS and NRPS pathways, and a biosynthetic pathway for balanol was proposed. |
| تدمد: | 1523-7052 1523-7060 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732622dd14d76d9c406a0f4f974acdfe https://doi.org/10.1021/acs.orglett.8b01543 |
| رقم الأكسشن: | edsair.doi.dedup.....732622dd14d76d9c406a0f4f974acdfe |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15237052 15237060 |
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