The HARMONIC project: Study design for assessment of cancer risks following cardiac fluoroscopy in childhood
| العنوان: | The HARMONIC project: Study design for assessment of cancer risks following cardiac fluoroscopy in childhood |
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| المؤلفون: | Vitalii Voloskyi, Steffen Dreger, Mark S. Pearce, Jérémie Dabin, Richard W Harbron, Johannes Hermen, Elena Bakhanova, Kristina Kjærheim, Choonsik Lee, Andreas Jahnen, Estelle Rage, David Borrego, Maria Grazia Andreassi, Vadim V. Chumak, Gaute Døhlen, Marie Odile Bernier, Utheya Thevathas, Hajo Zeeb, Eugenio Picano, Hilde Merete Olerud, S. Dreuil, Isabelle Thierry-Chef |
| المصدر: | Journal of Radiological Protection |
| بيانات النشر: | IOP Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, medicine.medical_treatment, Public Health, Environmental and Occupational Health, Cancer, General Medicine, medicine.disease, 3. Good health, 030218 nuclear medicine & medical imaging, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Epidemiology, Cohort, medicine, Dosimetry, Medical physics, Cancer development, Risk factor, Cardiac fluoroscopy, business, Waste Management and Disposal |
| الوصف: | The HARMONIC project (Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy in Paediatrics) is a European study aiming to improve our understanding of the long-term health risks from radiation exposures in childhood and early adulthood. Here, we present the study design for the cardiac component of HARMONIC. A pooled cohort of approximately 100,000 patients who underwent cardiac fluoroscopy procedures in Belgium, France, Germany, Italy, Norway, Spain or the UK, while aged under 22 years, will be established from hospital records and/or insurance claims data. Doses to individual organs will be estimated from dose indicators recorded at the time of examination, using a lookup-table-based dosimetry system produced using Monte Carlo radiation transport simulations and anatomically realistic computational phantom models. Information on beam geometry and x-ray energy spectra will be obtained from a representative sample of radiation dose structured reports (RDSRs). Uncertainties in dose estimates will be modelled using 2-dimensional Monte Carlo methods. The cohort will be followed up using national registries and insurance records (Germany) to determine vital status and cancer incidence. Information on organ transplantation (a major risk factor for cancer development) and/or other conditions predisposing to cancer will be obtained from national or local registries and health insurance data, depending on country. The relationship between estimated radiation dose and cancer risk will be investigated using regression modelling. Results will improve information for patients and parents and aid clinicians in managing and implementing changes to reduce radiation risks without compromising medical benefits. |
| تدمد: | 1361-6498 0952-4746 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732af6dacc924a9eed792f688c69b59e https://doi.org/10.1088/1361-6498/aba66d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....732af6dacc924a9eed792f688c69b59e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13616498 09524746 |
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