Increased soluble P-selectin levels in hepatitis C virus-related chronic hepatitis: correlation with viral load
| العنوان: | Increased soluble P-selectin levels in hepatitis C virus-related chronic hepatitis: correlation with viral load |
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| المؤلفون: | V. Paoletti, A. De Matteis, Giancarlo Labbadia, Cristiano M. Cardarello, Stefania Basili, Patrizia Ferroni, Antonino Musca, L. Donnarumma, Antonio Mammarella, Francesca Martini, P. P. Gazzaniga |
| المصدر: | Europe PubMed Central Scopus-Elsevier |
| مصطلحات موضوعية: | Adult, Male, Hepatitis C virus, thrombocytopenia, Biology, medicine.disease_cause, Chronic liver disease, General Biochemistry, Genetics and Molecular Biology, Liver disease, hemostatic abnormalities, In vivo, medicine, platelet activation, Humans, Platelet, cholesterol, liver disease, Platelet activation, Aged, Hepatitis, Cholesterol, HDL, Cholesterol, LDL, General Medicine, Hepatitis C, Chronic, Middle Aged, Viral Load, medicine.disease, P-Selectin, Immunology, RNA, Viral, Female, Viral load |
| الوصف: | Background Platelet functional abnormalities are commonly found in patients with chronic liver disease; however, their nature and clinical significance are still a matter of discussion. Methods Soluble P-selectin (sP-selectin, a marker of in vivo platelet activation) levels, lipid pattern, and clotting activity were investigated in 39 patients with histologically confirmed chronic C hepatitis. Results Serum factor VIIc ( P3/μL). Platelet-associated immunoglobulin G (PAIgG) was present in 30.8% of patients. Plasma sP-selectin levels were higher in hepatitis C patients compared with controls ( PConclusions The results obtained in this study support the hypothesis that HCV infection might be directly responsible for a condition of in vivo platelet activation in patients with chronic C hepatitis. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732c48a592610e4e82653d9d3db0eda1 http://europepmc.org/abstract/med/11523696 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....732c48a592610e4e82653d9d3db0eda1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |