A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK
| العنوان: | A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK |
|---|---|
| المؤلفون: | Jana Kretzschmar, Giulio Superti-Furga, Stefania Gonfloni, Marina Moro, Raffaella Mangano, Daniela Barilà, Dirk Bohmann |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Wiley, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | inorganic chemicals, Proto-Oncogene Proteins c-jun, Protein tyrosine phosphatase, Biology, Transfection, SH2 domain, General Biochemistry, Genetics and Molecular Biology, SH3 domain, Cell Line, Substrate Specificity, src Homology Domains, Mice, chemistry.chemical_compound, hemic and lymphatic diseases, Animals, Humans, Amino Acid Sequence, Phosphorylation, Tyrosine, Proto-Oncogene Proteins c-abl, neoplasms, Molecular Biology, Cell Nucleus, JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases, Enzyme Activation, Recombinant Proteins, Software, ABL, General Immunology and Microbiology, General Neuroscience, Tyrosine phosphorylation, Articles, Molecular biology, Settore BIO/18 - Genetica, enzymes and coenzymes (carbohydrates), chemistry, bacteria, Tyrosine kinase |
| الوصف: | The nuclear function of the c-Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We found that active nuclear Abl efficiently phosphorylate c-Jun, a transcription factor not previously known to be tyrosine phosphorylated. After phosphorylation of c-Jun by Abl on Tyr170, both proteins interacted via the SH2 domain of Abl. Surprisingly, elevated levels of c-Jun activated nuclear Abl, resulting in activation of the JNK serine/threonine kinase. This phosphorylation circuit generates nuclear tyrosine phosphorylation and represents a reversal of previously known signalling models. |
| تدمد: | 1460-2075 0261-4189 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736143d9198e8468029df5aae9ee037e https://doi.org/10.1093/emboj/19.2.273 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....736143d9198e8468029df5aae9ee037e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602075 02614189 |
|---|