What are the mechanisms of action of the different contraceptive methods to reduce the risk of ovarian cancer?
| العنوان: | What are the mechanisms of action of the different contraceptive methods to reduce the risk of ovarian cancer? |
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| المؤلفون: | Rafael Sánchez-Borrego, Manuel Sánchez-Prieto |
| المصدر: | The European Journal of Contraception & Reproductive Health Care. 26:79-84 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Ovarian Neoplasms, Oncology, medicine.medical_specialty, endocrine system diseases, Sterilization, Tubal, business.industry, Obstetrics and Gynecology, Disease, Malignancy, medicine.disease, female genital diseases and pregnancy complications, Salpingectomy, Contraception, Reproductive Medicine, Action (philosophy), Internal medicine, Contraceptive Agents, Female, medicine, Humans, Female, Pharmacology (medical), business, Ovarian cancer, Fallopian Tubes |
| الوصف: | Ovarian cancer (OvCa) is the deadliest gynaecologic malignancy. Knowing that OvCa, as a disease, has different origins has allowed us to relate them to the mechanisms of action of different contraceptive methods with the aim of evaluating the possibility of their use in reducing risk.This commentary review article will instead focus on the recent findings on the role of contraceptive methods in preventing of OvCa.Combined hormonal contraceptive (CHC) use is an effective method of chemoprevention for OvCa in the general population and in women with genetic disorders. Salpingectomy, better than tubal ligation, should be offered for ovarian/tubal/peritoneal cancer prevention. Progestogen-only methods can decrease the risk of OvCa via reduced menstrual bleeding and by changes in the hormonal environment that surrounds the ovary. IUDs of any type, through different mechanisms, decrease the risk of OvCa. Barrier methods prevent the passage of germs into the tubes and ovaries and the inflammatory state they produce.Most contraceptive methods have a mechanism of action that may favour a reduction in the risk of OvCa. The theories of incessant ovulation, retrograde menstruation, and that the fallopian tubes are the site of origin of a proportion of high-grade serous OvCa, have led to the recommendation that anovulatory methods, those that decrease menstrual bleeding, and those that blocked tubes, or even better, 'opportunistic salpingectomy' are a current approach to prevent OvCa in the population general and, above all, in the population at risk. |
| تدمد: | 1473-0782 1362-5187 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d24b69cd1f01b2df8e5f5a78bb287 https://doi.org/10.1080/13625187.2020.1849617 |
| رقم الأكسشن: | edsair.doi.dedup.....737d24b69cd1f01b2df8e5f5a78bb287 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14730782 13625187 |
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