Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism
| العنوان: | Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism |
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| المؤلفون: | Stacy Robertson, Eleanor Davies, Alexandra Riddell, Maria-Christina Zennaro, Hannah Saunders, Scott M. MacKenzie, Josie C. van Kralingen |
| المساهمون: | University of Glasgow, Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Fernandes Rosa, Fabio |
| المصدر: | Cancers Cancers, 2021, 13 (21), pp.5312. ⟨10.3390/cancers13215312⟩ Cancers, Vol 13, Iss 5312, p 5312 (2021) |
| مصطلحات موضوعية: | Cancer Research, Review, Bioinformatics, adrenocortical, 03 medical and health sciences, 0302 clinical medicine, Primary aldosteronism, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, microRNA, medicine, RC254-282, circulating, 030304 developmental biology, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 0303 health sciences, aldosterone, primary aldosteronism, business.industry, Diagnostic test, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Diagnostic marker, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, 3. Good health, Review article, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Circulating MicroRNA, Oncology, 030220 oncology & carcinogenesis, Potential biomarkers, Biomarker (medicine), biomarker, business |
| الوصف: | Simple Summary Many patients remain at increased risk of primary aldosteronism (PA) and its consequences due to the difficulty of accurate diagnosis. MicroRNAs circulating in the bloodstream are emerging as biomarkers for disease, particularly specific forms of cancer. In this review article, we argue that they may also have a role in the diagnosis of PA, if observed changes in the microRNA profile of PA tissue are reflected in circulating microRNAs, which can be sampled and analysed readily in a clinical setting. However, for various practical reasons, studies of potential diagnostic circulating microRNAs have often proved difficult to reproduce consistently. We describe these problems and how they might be overcome using, as an example, our design of the circulating microRNA arm of the ongoing ENS@T-HT project, which is intended to confirm whether circulating microRNAs can serve as biomarkers for PA. Abstract Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducing cardiovascular morbidity and mortality. Circulating microRNAs are emerging as potential biomarkers for a number of conditions due to their stability and accessibility. PA is known to alter microRNA expression in adrenocortical tissue; if these changes or their effects are mirrored in the circulating miRNA profile, then this could be exploited by a diagnostic test. However, the reproducibility of studies to identify biomarker-circulating microRNAs has proved difficult for other conditions due to a series of technical challenges. Therefore, any studies seeking to definitively identify circulating microRNA biomarkers of PA must address this in their design. To this end, we are currently conducting the circulating microRNA arm of the ongoing ENS@T-HT study. In this review article, we present evidence to support the utility of circulating microRNAs as PA biomarkers, describe the practical challenges to this approach and, using ENS@T-HT as an example, discuss how these might be overcome. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| DOI: | 10.3390/cancers13215312 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739d4dc33ea974c9c612863ba3c70f65 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....739d4dc33ea974c9c612863ba3c70f65 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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| DOI: | 10.3390/cancers13215312 |