A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene
| العنوان: | A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene |
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| المؤلفون: | Masakazu Nitta, Ryuzo Ueda, Tsutomu Takahashi, Shinsuke Iida, Hirokazu Komatsu, Chikara Mikuni, K Yamamoto, Masao Seto |
| المصدر: | Blood. 84:1226-1231 |
| بيانات النشر: | American Society of Hematology, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Lymphoma, Chromosomes, Human, Pair 22, Molecular Sequence Data, Immunology, Gene Expression, Chromosomal translocation, Locus (genetics), Biology, Polymerase Chain Reaction, Biochemistry, Translocation, Genetic, Chromosome Walking, Cyclin D1, Immunoglobulin lambda-Chains, Cyclins, Primer walking, medicine, Humans, RNA, Messenger, Gene, DNA Primers, Chromosomes, Human, Pair 14, Oncogene Proteins, Genetics, Messenger RNA, Base Sequence, Chromosomes, Human, Pair 11, Breakpoint, Chromosome Mapping, Genetic Variation, Cell Biology, Hematology, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Molecular biology, Introns, Leukemia, Immunoglobulin Light Chains, Immunoglobulin Heavy Chains |
| الوصف: | The 11q13 breakpoint region of t(11;14) (q13;q32), translocated to the Ig heavy chain locus at 14q32, has been designated as BCL-1 for B-cell leukemia/lymphoma-1, but the nature of the transcriptional unit has long remained unclear. Recently, the PRAD1 gene encoding cyclin D1, isolated from the 11q13 region, was proposed as a candidate BCL-1 gene on the basis of chromosome walking and concordant overexpression of PRAD1 mRNA in cell lines with t(11;14)(q13;q32). We report here molecular analysis of a variant translocation at the BCL-1 locus, t(11;22)(q13;q11), showing juxtaposition of the Ig light chain gene, Ig lambda, to the PRAD1 gene at its 3′ end, resulting in overexpression of PRAD1 mRNA. Because only the PRAD1 gene is present between the Ig heavy chain and light chain gene breakpoints, an identity between BCL-1 and the PRAD1/cyclin D1 gene is strongly indicated. |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7421c83cd50b1722dfd636da6c960ab0 https://doi.org/10.1182/blood.v84.4.1226.bloodjournal8441226 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7421c83cd50b1722dfd636da6c960ab0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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