A small case series about safety and effectiveness of a hypofractionated electron beam radiotherapy schedule in five fractions for facial non melanoma skin cancer among frail and elderly patients
| العنوان: | A small case series about safety and effectiveness of a hypofractionated electron beam radiotherapy schedule in five fractions for facial non melanoma skin cancer among frail and elderly patients |
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| المؤلفون: | Paolino De Lucia, Laura Molino, Francesco Garofalo, Laura Bottalico, Gianluca Ferini |
| المصدر: | Reports of Practical Oncology and Radiotherapy |
| بيانات النشر: | Via Medica, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Brachytherapy, brachytherapy, elderly patients, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Electron beam radiotherapy, electron beam radiotherapy, medicine, Radiotherapy dose, Radiology, Nuclear Medicine and imaging, Series (stratigraphy), skin cancer, business.industry, hypofractionated radiotherapy, medicine.disease, NMSC, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Marasmus, Radiology, Skin cancer, business, Non melanoma, Research Paper |
| الوصف: | Background: The aim of the study was to evaluate local control and toxicities of strongly hypofractionated electron beam radiotherapy (RT) in elderly and fragile patients with facial nonmelanoma skin cancer (NMSC). Materials and methods: We enrolled patients aged ≥ 65 years with facial NMSC, Karnofsky Performance Status (KPS) ≥ 40 and life expectancy ≥ 6 months, amenable neither to daily RT nor surgery. Radiotherapy consisted of 35 Gy, delivered with 6 MeV electron beam, in 5 fractions of 7 Gy/day twice a week (tw). Prescription isodoses were 100% for cT1–cT2 and 90% for cT3–cT4. Objective response was assessed clinically 4 and 8 weeks after the end of RT and then monitored every 6 months. Side effects were assessed according to the CTCAE scale. Results: 12 patients of median age 89.5 years with a total of 23 NMSC cN0 achieved a median follow-up time of 6 months (range 1–10), with total treatment compliance. 10/12 patients had a 40 ≤ KPS < 70 and 2/12 a 70 ≤ KPS < 90. 5/12 patients had synchronous lesions. 22/23 lesions were classified as T1–T2 and had complete response (CR), 1/23 as T4 with partial response (PR). Within 4 weeks after the end of treatment, G1 toxicity was reported for 12/23 lesions , G2 for 8/23, G3 for 3/23, G4 for 0/23, all disappeared 8 weeks later, with or without topical therapy. After last follow-up (1 June 2020) 1/12 patients died with PR from senile marasmus, 11/12 are alive with CR and widely tolerated toxicities. Conclusions: Extreme hypofractionation of radiotherapy dose for facial NMSC is effective, safe and suitable for elderly patients. |
| اللغة: | English |
| تدمد: | 2083-4640 1507-1367 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745dd0f025d5bda844052c567978dda6 http://europepmc.org/articles/PMC8086708 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....745dd0f025d5bda844052c567978dda6 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 20834640 15071367 |
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