Pharmacologically Active Ellagitannins from Terminalia myriocarpa
| العنوان: | Pharmacologically Active Ellagitannins from Terminalia myriocarpa |
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| المؤلفون: | Mohamed Marzouk, Nagwa M. M. Shalaby, Fatma A. Moharram, Sayed A. El-Toumy, Amany A. E. Ahmed |
| المصدر: | Planta Medica. 68:523-527 |
| بيانات النشر: | Georg Thieme Verlag KG, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Lipid Peroxides, Magnetic Resonance Spectroscopy, Stereochemistry, Vitexin, Pharmaceutical Science, Ethyl gallate, Terminalia myriocarpa, Pharmacology, Nitric Oxide, Antioxidants, Analytical Chemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Ellagitannin, Drug Discovery, Animals, Aspartate Aminotransferases, Gallic acid, Methyl gallate, Carbon Tetrachloride, chemistry.chemical_classification, Lipid peroxide, biology, Plant Extracts, Chemistry, Organic Chemistry, Alanine Transaminase, biology.organism_classification, Hydrolyzable Tannins, Rats, Plant Leaves, Complementary and alternative medicine, Terminalia, Molecular Medicine, Lipid Peroxidation, Tannins, Silymarin, Ellagic acid |
| الوصف: | A new ellagitannin, methyl (S)-flavogallonate (14) along with fourteen known compounds, gallic acid, methyl gallate, ethyl gallate, 2,3-di-O-[( S)-4,5,6,4',5',6'-hexahydroxybiphenyl-2,2'-diyldicarbonyl]-(alpha/beta)-D-glucopyranose (4), vitexin, isovitexin, orientin, iso-orientin, kaempferol 3-O-beta-D-rutinoside, rutin, neosaponarin, ellagic acid, flavogallonic acid (13), and (alpha/beta)-punicalagin (15) have been isolated from the leaves of Terminalia myriocarpa Heurck. Protective effect of the major and structurally related compounds 4, 13, 15 and the new compound 14 against CCl 4 -induced hepatotoxicity has been evaluated and compared, using adult male rats weighing 200-250 g. Serum levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lipid peroxide and nitric oxide production were significantly increased by administration of CCl 4 to rats and then reduced significantly only by treatment with compounds 4, 14 and 15 in a dose-dependent manner. Comparison of the protective properties of these compounds showed that compound 14 is more potent than compound 15 than 4 and that compound 13 has a non-significant effect at the used two dose levels. |
| تدمد: | 1439-0221 0032-0943 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c597ed4e142a03cc0fa581ad32bfbf https://doi.org/10.1055/s-2002-32549 |
| رقم الأكسشن: | edsair.doi.dedup.....74c597ed4e142a03cc0fa581ad32bfbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
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