Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria
| العنوان: | Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria |
|---|---|
| المؤلفون: | Jonathan C. Knowles, Hae-Won Kim, Sung-Hoon Lee, Tae-Su Jang, Hae-Hyoung Lee, Jung-Hwan Lee, Jin-Hwan Kwak, Hee-Won Han, Kapil D. Patel, Soo-Kyung Jun |
| المصدر: | Biomolecules, Vol 11, Iss 1028, p 1028 (2021) Biomolecules Volume 11 Issue 7 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Methicillin-Resistant Staphylococcus aureus, medicine.drug_class, Antibiotics, Colony Count, Microbial, multidrug-resistant bacteria, chemistry.chemical_element, 02 engineering and technology, Microbial Sensitivity Tests, Protein degradation, Biochemistry, Microbiology, Article, 03 medical and health sciences, chemistry.chemical_compound, Minimum inhibitory concentration, Selenium, Bacterial Proteins, antibacterial activity, synergistic effect, Drug Resistance, Multiple, Bacterial, Spectroscopy, Fourier Transform Infrared, selenium nanoparticles, medicine, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, Nanowires, Linezolid, Drug Synergism, biochemical phenomena, metabolism, and nutrition, 021001 nanoscience & nanotechnology, biology.organism_classification, Antimicrobial, bacterial infections and mycoses, QR1-502, Anti-Bacterial Agents, chemistry, Nanoparticles, 0210 nano-technology, Antibacterial activity, Bacteria, Enterococcus |
| الوصف: | In recent years, multidrug-resistant (MDR) bacteria have increased rapidly, representing a major threat to human health. This problem has created an urgent need to identify alternatives for the treatment of MDR bacteria. The aim of this study was to identify the antibacterial activity of selenium nanoparticles (SeNPs) and selenium nanowires (SeNWs) against MDR bacteria and assess the potential synergistic effects when combined with a conventional antibiotic (linezolid). SeNPs and SeNWs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), zeta potential, and UV-visible analysis. The antibacterial effects of SeNPs and SeNWs were confirmed by the macro-dilution minimum inhibitory concentration (MIC) test. SeNPs showed MIC values against methicillin-sensitive S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), and vancomycin-resistant enterococci (VRE) at concentrations of 20, 80, 320, and > 320 μg/mL, respectively. On the other hand, SeNWs showed a MIC value of > 320 μg/mL against all tested bacteria. Therefore, MSSA, MRSA, and VRSA were selected for the bacteria to be tested, and SeNPs were selected as the antimicrobial agent for the following experiments. In the time-kill assay, SeNPs at a concentration of 4X MIC (80 and 320 μg/mL) showed bactericidal effects against MSSA and MRSA, respectively. At a concentration of 2X MIC (40 and 160 μg/mL), SeNPs showed bacteriostatic effects against MSSA and bactericidal effects against MRSA, respectively. In the synergy test, SeNPs showed a synergistic effect with linezolid (LZD) through protein degradation against MSSA and MRSA. In conclusion, these results suggest that SeNPs can be candidates for antibacterial substitutes and supplements against MDR bacteria for topical use, such as dressings. However, for use in clinical situations, additional experiments such as toxicity and synergistic mechanism tests of SeNPs are needed. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e58341ecfe1d86111a2c7d4f95adc4 https://www.mdpi.com/2218-273X/11/7/1028 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....74e58341ecfe1d86111a2c7d4f95adc4 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |