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Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa

التفاصيل البيبلوغرافية
العنوان: Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa
المؤلفون: Raphael Kamng'ona, Ben Morton, Charlotte van der Veer, Grace Katha, Kelvin Mponda, James Nyirenda, Paul Kambiya, Catherine Anscombe, Jennifer E. Cornick, Kayla G. Barnes, Chimota Phiri, Prisca Matambo, Henry C. Mwandumba, Khuzwayo C. Jere, Jane Mallewa, Mulinda Nyirenda, Comfort Brown, Kwazizira Samson Mndolo, Jonathan Mandolo, Tamara Phiri, James Jafali, Jamie Rylance, Kondwani C. Jambo, Stephen B. Gordon, Ndaziona Peter Banda
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
NATURE COMMUNICATIONS
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Science, Antibiotics, General Physics and Astronomy, Disease, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Streptococcus pneumoniae, Pandemic, medicine, 030212 general & internal medicine, Multidisciplinary, biology, business.industry, General Chemistry, medicine.disease, 3. Good health, 030104 developmental biology, Staphylococcus aureus, Immunoglobulin M, Immunology, Coinfection, biology.protein, Antibody, business
الوصف: Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.
وصف الملف: application/pdf
اللغة: English
تدمد: 2041-1723
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750c0a6a6bae8a014a61dc73d083dbf8
https://doaj.org/article/5ac0ac388c3f4d77be678f53c3d46ebe
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....750c0a6a6bae8a014a61dc73d083dbf8
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20411723