The absence of muscle segment homeobox 2 leads to the pyroptosis of ameloblasts by inducing squamous epithelial hyperplasia in the enamel organ
| العنوان: | The absence of muscle segment homeobox 2 leads to the pyroptosis of ameloblasts by inducing squamous epithelial hyperplasia in the enamel organ |
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| المؤلفون: | Chang Xu, Jingkun Bai, Juanjuan Zhang, Chuanji Li, Xiaoying Liu, Ying Xu, Ying Zhao, Jinyue Li, Mengge Xu, Yong Ren, Yuguang Gao, Yan Sun |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Keratin, medicine, chemistry.chemical_classification, Enamel paint, pyroptosis, Enamel organ, Pyroptosis, Original Articles, Cell Biology, enamel development, Phenotype, ameloblast, Epithelium, Cell biology, stomatognathic diseases, 030104 developmental biology, medicine.anatomical_structure, chemistry, squamous epithelial hyperplasia, 030220 oncology & carcinogenesis, visual_art, visual_art.visual_art_medium, Molecular Medicine, Homeobox, Original Article, Ameloblast, MSX2 |
| الوصف: | Muscle segment homeobox 2 (MSX2) has been confirmed to be involved in the regulation of early tooth development. However, the role of MSX2 has not been fully elucidated in enamel development. To research the functions of MSX2 in enamel formation, we used a Msx2 −/− (KO) mouse model with no full Msx2 gene. In the present study, the dental appearance and enamel microstructure were detected by scanning electron microscopy and micro‐computed tomography. The results showed that the absence of Msx2 resulted in enamel defects, leading to severe tooth wear in KO mice. To further investigate the mechanism behind the phenotype, we performed detailed histological analyses of the enamel organ in KO mice. We discovered that ameloblasts without Msx2 could secrete a small amount of enamel matrix protein in the early stage. However, the enamel epithelium occurred squamous epithelial hyperplasia and partial keratinization in the enamel organ during subsequent developmental stages. Ameloblasts depolarized and underwent pyroptosis. Overall, during the development of enamel, MSX2 affects the formation of enamel by regulating the function of epithelial cells in the enamel organ. |
| تدمد: | 1582-4934 1582-1838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750d4fba6b3be877f7b5664201dba900 https://doi.org/10.1111/jcmm.16646 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....750d4fba6b3be877f7b5664201dba900 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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