Tailoring Kidney Transport of Organic Dyes with Low-Molecular-Weight PEGylation
| العنوان: | Tailoring Kidney Transport of Organic Dyes with Low-Molecular-Weight PEGylation |
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| المؤلفون: | Siqing Li, Jie Zheng, Bujie Du, Jason Lin, Xingya Jiang, Mengxiao Yu, Yingyu Huang |
| المصدر: | Bioconjugate Chemistry. 31:241-247 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Biomedical Engineering, Pharmaceutical Science, Bioengineering, 02 engineering and technology, Conjugated system, Kidney, 01 natural sciences, Polyethylene Glycols, chemistry.chemical_compound, PEG ratio, Animals, Fluorescein, Coloring Agents, Pharmacology, Mice, Inbred BALB C, Ethylene oxide, 010405 organic chemistry, Optical Imaging, Organic Chemistry, Kidney metabolism, Biological Transport, 021001 nanoscience & nanotechnology, Small molecule, 0104 chemical sciences, Molecular Weight, chemistry, Biophysics, PEGylation, 0210 nano-technology, Ethylene glycol, Biotechnology |
| الوصف: | [Image: see text] Subtle changes in size can induce distinct responses of the body to hard nanomaterials; however, it is largely unknown whether just a few ethylene oxide unit differences in soft poly(ethylene glycol) (PEG) molecules could significantly alter the renal clearance of small molecules. By systematically investigating in vivo transport of the representative renal clearable organic dyes, IRDye800CW after being conjugated with a series of PEG molecules with molecular weight (MW) below 10 kDa, we found a MW-dependent scaling law: PEG45 (MW = 2100 Da) is an optimized MW to generate the most efficient renal clearance for IRDye800CW by expediting the glomerular filtration of organic dyes and reducing their nonspecific interactions with background tissue. Moreover, the uniqueness of PEG45 can be generalized to other organic dyes such as ZW800-1 and fluorescein. This finding highlights the importance of low-MW PEGylation in tailoring in vivo transport of organic fluorophores, which would broaden their biomedical applications. |
| تدمد: | 1520-4812 1043-1802 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754f0bb8d85ee80eb7ce9011dd507d0b https://doi.org/10.1021/acs.bioconjchem.9b00707 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....754f0bb8d85ee80eb7ce9011dd507d0b |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204812 10431802 |
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