Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma Suspect, and Mild Open-Angle Glaucoma Patients: A Randomized, Controlled, Prospective, Pilot Study
| العنوان: | Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma Suspect, and Mild Open-Angle Glaucoma Patients: A Randomized, Controlled, Prospective, Pilot Study |
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| المؤلفون: | Adam Bleeker, Steven J Ferguson, John P. Berdahl, Tanner J. Ferguson, Jeremy J Kudrna, Michael Greenwood, Russell J Swan, Ramu G Sudhagoni, Brandon J Baartman |
| المصدر: | Ophthalmology and Therapy, Vol 9, Iss 4, Pp 981-992 (2020) Ophthalmology and Therapy |
| بيانات النشر: | Adis, Springer Healthcare, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Intraocular pressure, Open angle glaucoma, genetic structures, Glaucoma, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Steady-state pattern electroretinogram, Ophthalmology, medicine, 0101 mathematics, Lead (electronics), Original Research, business.industry, 010102 general mathematics, Multi-pressure dial, Glaucoma suspect, Pattern electroretinography, RE1-994, medicine.disease, eye diseases, Private practice, 030221 ophthalmology & optometry, sense organs, High intraocular pressure, business, Glaucoma management |
| الوصف: | Introduction This study evaluates the effects of the multi-pressure dial (MPD) on steady-state pattern electroretinography (ss-pERG) parameters. The study is a randomized, controlled, prospective, pilot trial in a private practice setting with ocular hypertensive (OHT), glaucoma suspect, and open-angle glaucoma (OAG) subjects. Methods This study included nine patients (64 ± 9.0 years, nine female) with OHT, glaucoma suspect, or mild OAG. One eye of each subject was randomized to receive negative periocular pressure, while the contralateral eye served as the intrasubject control through the goggle without negative pressure. The Diopsys High Contrast Sensitivity ss-pERG protocol was conducted on both eyes of each subject while wearing the MPD device. Application of negative periocular pressure was set at 50% of baseline intraocular pressure for each study eye. Results Following 2 h of negative periocular pressure application, the difference in MagnitudeD (MagD) from baseline for eyes randomized to receive negative periocular pressure (+ 0.17 versus − 0.26) was statistically significant (p = 0.023). Over the same period, the change in MagD/Magnitude (MagD/Mag ratio) from baseline for eyes randomized to receive negative periocular pressure was also higher (+ 0.14 versus − 0.16), compared to the control eyes, approached significance (p = 0.059). Conclusions Following 2 h of MPD wear, the measured MagD and MagD/Mag ratio improved compared to control, suggesting that negative periocular pressure application to the anterior globe can lead to short-term improvement in one measure of retinal ganglion cell function. |
| اللغة: | English |
| تدمد: | 2193-6528 2193-8245 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7569854659427ab1007b544da81cc603 https://doaj.org/article/2a68dea0a2b741f487c05c1dc0049fdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7569854659427ab1007b544da81cc603 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 21936528 21938245 |
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