Epizootic hemorrhagic disease virus (EHDV) is a Culicoides biting midge-transmitted orbivirus (family Reoviridae) of wild and domestic ruminants and is an important pathogen of white-tailed deer (Odocoileus virginianus). Historically, only two serotypes, EHDV-1 and EHDV-2, have been known to be endemic in the US. However, in 2006, an exotic serotype (EHDV-6) was first detected in the US by a long-term passive surveillance system for EHDV and bluetongue viruses. Here we report EHDV-6 detections made through these passive surveillance efforts by the Southeastern Cooperative Wildlife Disease Study (University of Georgia, Athens, Georgia, USA) and the National Veterinary Services Laboratories (US Department of Agriculture, Ames, Iowa, USA) over a 10-yr period (2006-15). The results demonstrated that EHDV-6 was detected from ruminants every year since 2006 and was wide-spread in the central and eastern US, providing evidence that EHDV-6 is likely now established in the US. Federal Aid to Wildlife Restoration Act; US Department of Agriculture, Animal Plant Health Inspection Service We are grateful for the continued financial support from the member states of the Southeastern Cooperative Wildlife Disease Study provided by the Federal Aid to Wildlife Restoration Act (50 Stat. 917) and through long-term cooperative agreements with the US Department of Agriculture, Animal Plant Health Inspection Service. This study was made possible by the efforts of numerous wildlife biologists, veterinarians, and technicians affiliated with state and federal wildlife agencies that annually submitted case data and provided field samples for virus isolation. Additional samples and virus isolates were provided by Newport Laboratories, Michigan Department of Natural Resources Wildlife Diseases Laboratory, Texas A&M Veterinary Medical Diagnostic Laboratory, Indiana Animal Disease Diagnostic Laboratory, and Rollins Animal Disease Diagnostic Laboratory. Laboratory and data management support at SCWDS was provided by D. G. Mead, C. McElwee, and J. Brewton. Public domain – authored by a U.S. government employee
