Limited utility of plasma elafin as a biomarker for skin graft‐versus‐host disease following allogeneic stem cell transplantation
| العنوان: | Limited utility of plasma elafin as a biomarker for skin graft‐versus‐host disease following allogeneic stem cell transplantation |
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| المؤلفون: | Biju George, Kavitha M Lakshmi, Vikram Mathews, Susanne Pulimood, Ezhilpavai Mohanan, A. Srivastava, Poonkuzhali Balasubramanian, Lakshmanan Jeyaseelan, Dincy Peter, Leni George, Ajay Abraham, G. Mahabal |
| المصدر: | Clinical and Experimental Dermatology. 46:1482-1487 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Graft vs Host Disease, chemical and pharmacologic phenomena, Dermatology, Disease, Gastroenterology, Diagnosis, Differential, Young Adult, immune system diseases, Internal medicine, medicine, Humans, Child, Prospective cohort study, business.industry, Hematopoietic Stem Cell Transplantation, Infant, Exanthema, Middle Aged, medicine.disease, Rash, Elafin, Transplantation, surgical procedures, operative, Graft-versus-host disease, Child, Preschool, Biomarker (medicine), Female, Stem cell, medicine.symptom, business, Biomarkers |
| الوصف: | Background Acute cutaneous graft-versus-host disease (acGVHD) following haematopoietic stem cell transplant (HSCT) is common but difficult to distinguish from other causes of rash. Plasma elafin has been proposed as a diagnostic and prognostic biomarker of skin GVHD. Aim To evaluate the role of plasma elafin as a biomarker in acGVHD in an Indian population. Methods Plasma elafin was evaluated in a prospective study of HSCT recipients, conducted over 2 years, taking measurements at baseline and at onset of skin rash after HSCT. Patients were categorized into those with GVHD rash, those with non-GVHD rash and those with no rash and the three groups were compared. Results Two hundred and sixty-one patients with a median age of 16 years (range 1–61 years) and a male predominance (175 : 86 M/F) underwent HSCT during the study period: 56 patients in the GVHD group, 49 in the non-GVHD group and 156 in the no-rash group. The median baseline elafin was similar in all three groups. At the onset of rash, median elafin level was similar between GVHD and non-GVHD rash (34 549 vs. 32 077 pg/mL; P = 0.58) and between GVHD and no rash (34 549 vs. 26 197 pg/mL; P = 0.08). A rise in elafin from baseline was significantly different between GVHD and no rash (P < 0.001) but not between GVHD and non-GVHD rash (P = 0.44). Conclusion The utility of plasma elafin as a biomarker of skin GVHD is very limited. Plasma elafin, although elevated in cutaneous GVHD, is not helpful in distinguishing between GVHD rash and other causes of rash following HSCT. |
| تدمد: | 1365-2230 0307-6938 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b03ba5aa897daaac34ab8982f9e03e https://doi.org/10.1111/ced.14785 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....75b03ba5aa897daaac34ab8982f9e03e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652230 03076938 |
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