Antifibrotic and Regenerative Effects of Treamid in Pulmonary Fibrosis
| العنوان: | Antifibrotic and Regenerative Effects of Treamid in Pulmonary Fibrosis |
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| المؤلفون: | Sergey G. Morozov, M. A. Zhukova, Fedor N. Novikov, E. S. Pan, N. N. Ermakova, Aslan Amirkhanovich Kubatiev, Darius Widera, Vladimir Nebolsin, L. A. Sandrikina, E. G. Skurikhin, O. V. Pershina, A. M. Dygai, A. V. Pakhomova, V. A. Krupin |
| المصدر: | International Journal of Molecular Sciences Volume 21 Issue 21 International Journal of Molecular Sciences, Vol 21, Iss 8380, p 8380 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pathology, Indoles, Treamid, Apoptosis, lcsh:Chemistry, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Mice, 0302 clinical medicine, Pulmonary fibrosis, Dicarboxylic Acids, lcsh:QH301-705.5, Lung, Spectroscopy, General Medicine, Pirfenidone, respiratory system, Computer Science Applications, medicine.anatomical_structure, Nintedanib, medicine.drug, medicine.medical_specialty, Endothelium, Pyridones, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Bleomycin, medicine, Animals, Humans, Physical and Theoretical Chemistry, Progenitor cell, Molecular Biology, endothelial progenitor cells, pulmonary fibrosis, business.industry, Regeneration (biology), Organic Chemistry, Endothelial Cells, medicine.disease, Fibrosis, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Capillaries, Mice, Inbred C57BL, 030104 developmental biology, 030228 respiratory system, chemistry, lcsh:Biology (General), lcsh:QD1-999, regeneration, business |
| الوصف: | Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by interstitial fibrosis and progressive respiratory failure. Pirfenidone and nintedanib slow down but do not stop the progression of IPF. Thus, new compounds with high antifibrotic activity and simultaneously regenerative activity are an unmet clinical need. Recently, we showed that Treamid can help restoring the pancreas and testicular tissue in mice with metabolic disorders. We hypothesized that Treamid may be effective in antifibrotic therapy and regeneration of damaged lung tissue in pulmonary fibrosis. In this study, experiments were performed on male C57BL/6 mice with bleomycin-induced pulmonary fibrosis. We applied histological and immunohistochemical methods, ELISA, and assessed the expression of markers of endothelial and epithelial cells in primary cultures of CD31+ and CD326+ lung cells. Finally, we evaluated esterase activity and apoptosis of lung cells in vitro. Our data indicate that Treamid exhibits antifibrotic activity in mice with pulmonary fibrosis and has a positive effect on capillaries of the lungs. Treamid also increases the number of endothelial progenitor cells in the lungs of animals with pulmonary fibrosis. Lastly, Treamid increases esterase activity and decreases apoptosis of CD31+ lung cells in vitro. Based on these findings, we suggest that Treamid may represent a promising compound for the development of new antifibrotic agents, which are capable of stimulating regeneration of lung endothelium in IPF patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b13e960fceb545af7122083ca70de9 http://europepmc.org/articles/PMC7664690 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....75b13e960fceb545af7122083ca70de9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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