Efficacy of a single botulinum toxin A injection for distal tarsal tunnel syndrome: A protocol for a randomized, double-blinded trial
| العنوان: | Efficacy of a single botulinum toxin A injection for distal tarsal tunnel syndrome: A protocol for a randomized, double-blinded trial |
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| المؤلفون: | Omar Baarini, Steven R. Edwards, Beng J. Tan |
| المصدر: | Contemporary Clinical Trials Communications Contemporary Clinical Trials Communications, Vol 21, Iss, Pp 100725-(2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, FHSQ, foot health status questionnaire, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Study protocol, Medicine, Abductor hallucis muscle, 030212 general & internal medicine, Tarsal tunnel, Tibial nerve, VAS, visual analog scale, Pharmacology, Protocol (science), lcsh:R5-920, DTTS, distal tarsal tunnel syndrome, BTX-A, botulinum toxin A injection, business.industry, General Medicine, Tarsal tunnel syndrome, medicine.disease, Surgery, Clinical trial, medicine.anatomical_structure, Corticosteroid injection, Inclusion and exclusion criteria, CSI, corticosteroid injection, Botulinum toxin a, business, lcsh:Medicine (General), 030217 neurology & neurosurgery |
| الوصف: | Introduction Distal tarsal tunnel syndrome (DTTS) is characterised by compression of the tibial nerve as it passes underneath the abductor hallucis muscle belly. There is no current consensus on treatment for DTTS. This study was conducted to compare and evaluate the effect of ultrasound-guided botulinum toxin A (BTX-A) versus ultrasound-guided corticosteroid injection (CSI) for the treatment of DTTS. Methods This study was a single-centre, randomized, and double-blinded trial. The study protocol was submitted to the local ethics committee board and subsequently registered in a research registry. 88 patients with DTTS were randomly divided into 2 groups according to the treatment received. The patients were evaluated over 12 weeks. Evaluation was via the Foot Health Status Questionnaire (FHSQ). The primary outcome measures were pain and the secondary outcomes were function and the use of oral analgesics. All of the assessments were performed at baseline and at 3, 6, and 12 weeks after treatment. Results This is a randomized controlled trial evaluating the efficacy of BTX-A versus CSI in the treatment of DTTS. This study has limited inclusion and exclusion criteria and a well-controlled intervention. Conclusions The results of this trial will provide more evidence on which method can better treat DTTS. Trial registration We have registered this trial with the Australian New Zealand Clinical Trials Registry and the temporary trial number is 380,105. |
| تدمد: | 2451-8654 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c0abf456388e76a29faf511141d527 https://pubmed.ncbi.nlm.nih.gov/33553799 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....75c0abf456388e76a29faf511141d527 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 24518654 |
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